Ncam1 neural cell adhesion molecule 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ncam1provided by RGD
Official Full Name: neural cell adhesion molecule 1provided by RGD
Primary source: RGD:67378
See related: EnsemblRapid:ENSRNOG00000031890 AllianceGenome:RGD:67378
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cd56; Ncam; N-CAM; NCAMC; NCAM-1; NCAM-C; N-CAM-1
Summary: Enables LRR domain binding activity and phosphatase binding activity. Involved in several processes, including axon development; medium-term memory; and response to ethanol. Located in cytoplasm and neuronal cell body. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and synaptic membrane. Used to study middle cerebral artery infarction and opioid abuse. Biomarker of several diseases, including alcohol use disorder; congestive heart failure; depressive disorder; morphine dependence; and myocardial infarction. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; bipolar disorder; drug dependence; middle cerebral artery infarction; and nicotine dependence. Orthologous to human NCAM1 (neural cell adhesion molecule 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 216.9), Kidney (RPKM 51.7) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q23

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (58762088..59062131, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (49865629..50165687, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (53836797..54134881, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The dynamic TRPV2 ion channel proximity proteome reveals functional links of calcium flux with cellular adhesion factors NCAM and L1CAM in neurite outgrowth.
Title: The dynamic TRPV2 ion channel proximity proteome reveals functional links of calcium flux with cellular adhesion factors NCAM and L1CAM in neurite outgrowth.
The effects of induced type I diabetes on developmental regulation of GDNF, NRTN, and NCAM proteins in the dentate gyrus of male rat offspring.
Title: The effects of induced type I diabetes on developmental regulation of GDNF, NRTN, and NCAM proteins in the dentate gyrus of male rat offspring.
After unilateral avulsion of the recurrent laryngeal nerve, the expression of polysialylated NCAM in the ipsilateral nucleus ambiguus was correlated with the proliferation and the differentiation of neural cells.
Title: Polysialylated Neural Cell Adhesion Molecule Supports Regeneration of Neurons in the Nucleus Ambiguus After Unilateral Recurrent Laryngeal Nerve Avulsion in Adult Rats.
A rat genetic model of vulnerability/resistance to stress-induced depression showed differential pattern of expression of BDNF, trkB, and PSA-NCAM in the hippocampus.
Title: Effect of Acute Stress on the Expression of BDNF, trkB, and PSA-NCAM in the Hippocampus of the Roman Rats: A Genetic Model of Vulnerability/Resistance to Stress-Induced Depression.
Our results strongly support the hypothesis that PSA-NCAMs play a proaggregatory role in the fasciculatory process
Title: Axonal fasciculation and the role of polysialic acid-neural cell adhesion molecule in rat cortical neurons.
CD56(140kD) up-regulation plays a pivotal role in the pathogenesis of ischemic cardiomyopathy.
Title: The 140-kD isoform of CD56 (NCAM1) directs the molecular pathogenesis of ischemic cardiomyopathy.
Stressed animals exhibited an increase in NCAM mRNA expression in the hippocampus, but not in the prefrontal cortex. The synaptosomal NCAM of the hippocampus was markedly polysialylated, while cortical PSA-NCAM was significantly decreased.
Title: Effects of chronic social isolation on Wistar rat behavior and brain plasticity markers.
A serine-to-alanine exchange at position 774 of NCAM resulted in decreased activation of the cAMP response element binding protein and decreased neurite outgrowth after NCAM stimulation in neuroblastoma cells
Title: Phosphorylation of serine 774 of the neural cell adhesion molecule is necessary for cyclic adenosine monophosphate response element binding protein activation and neurite outgrowth.
FGL triggers a long-lasting enhancement of synaptic transmission and long-term potentiation in hippocampal CA1 neurons by a facilitated synaptic delivery of AMPA receptors.
Title: Facilitation of AMPA receptor synaptic delivery as a molecular mechanism for cognitive enhancement.
NCAM-derived peptide plannexin can protect immature neurons in vivo; however, in a model of status epilepticus plannexin-treated animals do not reveal any neuroprotective effects of plannexin on mature neurons.
Title: Impact of the NCAM derived mimetic peptide plannexin on the acute cellular consequences of a status epilepticus.

Submit: New GeneRIF Correction See all GeneRIFs (66)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:226059

NCAM1 (e-PCR)
- UniSTS:504082

D8Arb10 (e-PCR)
- UniSTS:240427

RH132569 (e-PCR)
- UniSTS:215852

D8Arb23 (e-PCR)
- UniSTS:240435

D8Mit2 (e-PCR)
- UniSTS:119612

D8Rat44 (e-PCR)
- UniSTS:119110

BF388149 (e-PCR)
- UniSTS:260940

BF402045 (e-PCR)
- UniSTS:245847

Ncam (e-PCR), detects polymorphism
- UniSTS:226144

RH138949 (e-PCR)
- UniSTS:221035

BF400138 (e-PCR)
- UniSTS:244856

RH142318 (e-PCR)
- UniSTS:231565

RH134243 (e-PCR)
- UniSTS:217525

D8Rat215 (e-PCR), detects polymorphism
- UniSTS:228281

RH143130 (e-PCR)
- UniSTS:232377

Ncam1 (e-PCR), detects polymorphism
- UniSTS:532433

D1S2854 (e-PCR)
- UniSTS:50145

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables LRR domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables cytoskeletal protein binding	TAS Traceable Author Statement more info	PubMed
enables fibroblast growth factor receptor binding	TAS Traceable Author Statement more info	PubMed
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables phosphatase binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in axonal fasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in behavioral response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	TAS Traceable Author Statement more info	PubMed
acts_upstream_of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to ethanol	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to fluoride	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to molecule of bacterial origin	IEP Inferred from Expression Pattern more info	PubMed
involved_in commissural neuron axon guidance	ISO Inferred from Sequence Orthology more info
involved_in epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in epithelial to mesenchymal transition	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within homotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in learning or memory	IDA Inferred from Direct Assay more info	PubMed
involved_in learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in medium-term memory	IEP Inferred from Expression Pattern more info	PubMed
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organismal response to stress	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in peripheral nervous system axon regeneration	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within positive regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of exocyst assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of semaphorin-plexin signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cocaine	IDA Inferred from Direct Assay more info	PubMed
involved_in response to lead ion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to morphine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to oxidative stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in thalamus development	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in growth cone	TAS Traceable Author Statement more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: neural cell adhesion molecule 1

NP_001382636.1

EC 2.7.11.1

NP_001382637.1

EC 2.7.11.1

NP_001382638.1

EC 2.7.11.1

NP_001382639.1

EC 2.7.11.1

NP_113709.1

EC 2.7.11.1

XP_006243048.1

EC 2.7.11.1

XP_017450949.1

EC 2.7.11.1

XP_017450950.1

EC 2.7.11.1

XP_017450952.1

EC 2.7.11.1

XP_038936736.1

EC 2.7.11.1

XP_038936742.1

EC 2.7.11.1

XP_038936743.1

EC 2.7.11.1

XP_063120970.1

EC 2.7.11.1

XP_063120971.1

EC 2.7.11.1

XP_063120972.1

EC 2.7.11.1

XP_063120973.1

EC 2.7.11.1

XP_063120974.1

EC 2.7.11.1

XP_063120975.1

EC 2.7.11.1

XP_063120976.1

EC 2.7.11.1

XP_063120977.1

EC 2.7.11.1

XP_063120978.1

EC 2.7.11.1

XP_063120979.1

EC 2.7.11.1

XP_063120980.1

EC 2.7.11.1

XP_063120981.1

EC 2.7.11.1

XP_063120982.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395707.2 → NP_001382636.1 neural cell adhesion molecule 1 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A0G2K0M8

Conserved Domains (9) summary

cd05730
Location:211 → 308

IgI_3_NCAM-1; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of the I-set of IgSF domains

cd05869
Location:307 → 413

IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)

smart00410
Location:124 → 190

IG_like; Immunoglobulin like

cd00063
Location:509 → 606

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam05109
Location:836 → 1127

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam00041
Location:613 → 695

fn3; Fibronectin type III domain

pfam13927
Location:422 → 494

Ig_3; Immunoglobulin domain

cd00096
Location:433 → 437

Ig; Ig strand B [structural motif]

cd05865
Location:20 → 116

IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains
NM_001395708.2 → NP_001382637.1 neural cell adhesion molecule 1 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

F1LUV9, Q3T1H3

Related

ENSRNOP00000046828.6, ENSRNOT00000047666.7

Conserved Domains (8) summary

cd05730
Location:211 → 308

IgI_3_NCAM-1; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of the I-set of IgSF domains

cd05869
Location:307 → 403

IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)

smart00409
Location:124 → 190

IG; Immunoglobulin

cd00063
Location:499 → 596

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:603 → 685

fn3; Fibronectin type III domain

pfam13927
Location:412 → 484

Ig_3; Immunoglobulin domain

cd00096
Location:423 → 427

Ig; Ig strand B [structural motif]

cd05865
Location:20 → 116

IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains
NM_001395709.1 → NP_001382638.1 neural cell adhesion molecule 1 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A6J4C5
NM_001395710.1 → NP_001382639.1 neural cell adhesion molecule 1 isoform 4 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A6J4C5

Related

ENSRNOP00000080203.2, ENSRNOT00000099284.2

Conserved Domains (8) summary

cd05730
Location:211 → 308

IgI_3_NCAM-1; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of the I-set of IgSF domains

cd05869
Location:307 → 403

IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)

smart00409
Location:124 → 190

IG; Immunoglobulin

cd00063
Location:499 → 596

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:603 → 684

fn3; Fibronectin type III domain

pfam13927
Location:412 → 484

Ig_3; Immunoglobulin domain

cd00096
Location:423 → 427

Ig; Ig strand B [structural motif]

cd05865
Location:20 → 116

IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains
NM_031521.4 → NP_113709.1 neural cell adhesion molecule 1 isoform 5 precursor

See identical proteins and their annotated locations for NP_113709.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

P13596

UniProtKB/TrEMBL

F1LUV9

Conserved Domains (8) summary

cd05730
Location:211 → 308

Ig3_NCAM-1_like; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

cd05865
Location:20 → 115

Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1

cd05869
Location:307 → 413

Ig5_NCAM-1; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

smart00408
Location:429 → 497

IGc2; Immunoglobulin C-2 Type

smart00410
Location:422 → 500

IG_like; Immunoglobulin like

cd00063
Location:509 → 606

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:218 → 305

I-set; Immunoglobulin I-set domain

pfam00041
Location:613 → 694

fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

58762088..59062131 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017595463.3 → XP_017450952.1 neural cell adhesion molecule 1 isoform X13

UniProtKB/TrEMBL

F1LNY3, F1LUV9

Related

ENSRNOP00000079021.2, ENSRNOT00000113915.2
XM_017595461.3 → XP_017450950.1 neural cell adhesion molecule 1 isoform X6

UniProtKB/TrEMBL

A0A0G2K0M8, A0A8I5ZLW8

Related

ENSRNOP00000091588.2, ENSRNOT00000099180.2
XM_063264901.1 → XP_063120971.1 neural cell adhesion molecule 1 isoform X5
XM_063264907.1 → XP_063120977.1 neural cell adhesion molecule 1 isoform X12
XM_063264900.1 → XP_063120970.1 neural cell adhesion molecule 1 isoform X4
XM_063264904.1 → XP_063120974.1 neural cell adhesion molecule 1 isoform X9

Related

ENSRNOP00000048442.6, ENSRNOT00000042281.8
XM_017595460.3 → XP_017450949.1 neural cell adhesion molecule 1 isoform X3

UniProtKB/TrEMBL

A0A0G2K0M8
XM_063264906.1 → XP_063120976.1 neural cell adhesion molecule 1 isoform X11
XM_063264905.1 → XP_063120975.1 neural cell adhesion molecule 1 isoform X10
XM_039080808.2 → XP_038936736.1 neural cell adhesion molecule 1 isoform X2

UniProtKB/TrEMBL

A0A0G2K0M8

Related

ENSRNOP00000071509.1, ENSRNOT00000082257.3

Conserved Domains (9) summary

cd05730
Location:211 → 308

IgI_3_NCAM-1; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of the I-set of IgSF domains

cd05869
Location:307 → 413

IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)

smart00409
Location:124 → 190

IG; Immunoglobulin

cd00063
Location:509 → 606

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam05109
Location:840 → 1131

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam00041
Location:618 → 699

fn3; Fibronectin type III domain

pfam13927
Location:422 → 494

Ig_3; Immunoglobulin domain

cd00096
Location:433 → 437

Ig; Ig strand B [structural motif]

cd05865
Location:20 → 116

IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains
XM_006242986.4 → XP_006243048.1 neural cell adhesion molecule 1 isoform X1

UniProtKB/TrEMBL

A0A0G2K0M8

Conserved Domains (8) summary

cd05730
Location:211 → 308

Ig3_NCAM-1_like; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

cd05865
Location:20 → 115

Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1

cd05869
Location:307 → 413

Ig5_NCAM-1; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

smart00408
Location:429 → 497

IGc2; Immunoglobulin C-2 Type

smart00410
Location:422 → 500

IG_like; Immunoglobulin like

cd00063
Location:509 → 606

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:218 → 305

I-set; Immunoglobulin I-set domain

pfam00041
Location:618 → 700

fn3; Fibronectin type III domain
XM_063264903.1 → XP_063120973.1 neural cell adhesion molecule 1 isoform X8
XM_063264902.1 → XP_063120972.1 neural cell adhesion molecule 1 isoform X7
XM_063264912.1 → XP_063120982.1 neural cell adhesion molecule 1 isoform X20
XM_063264910.1 → XP_063120980.1 neural cell adhesion molecule 1 isoform X16
XM_039080815.1 → XP_038936743.1 neural cell adhesion molecule 1 isoform X19

UniProtKB/TrEMBL

A0A8I5ZQ32, A6J4C5

Conserved Domains (8) summary

cd05730
Location:211 → 308

IgI_3_NCAM-1; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of the I-set of IgSF domains

cd05869
Location:307 → 413

IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)

smart00409
Location:124 → 190

IG; Immunoglobulin

cd00063
Location:509 → 606

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:613 → 694

fn3; Fibronectin type III domain

pfam13927
Location:422 → 494

Ig_3; Immunoglobulin domain

cd00096
Location:433 → 437

Ig; Ig strand B [structural motif]

cd05865
Location:20 → 116

IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains
XM_063264911.1 → XP_063120981.1 neural cell adhesion molecule 1 isoform X18
XM_039080814.1 → XP_038936742.1 neural cell adhesion molecule 1 isoform X17

UniProtKB/TrEMBL

A6J4C5

Conserved Domains (8) summary

cd05730
Location:211 → 308

IgI_3_NCAM-1; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of the I-set of IgSF domains

cd05869
Location:307 → 413

IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)

smart00409
Location:124 → 190

IG; Immunoglobulin

cd00063
Location:509 → 606

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:618 → 699

fn3; Fibronectin type III domain

pfam13927
Location:422 → 494

Ig_3; Immunoglobulin domain

cd00096
Location:433 → 437

Ig; Ig strand B [structural motif]

cd05865
Location:20 → 116

IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains
XM_063264909.1 → XP_063120979.1 neural cell adhesion molecule 1 isoform X15
XM_063264908.1 → XP_063120978.1 neural cell adhesion molecule 1 isoform X14