Hsph1 heat shock protein family H (Hsp110) member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hsph1provided by RGD
Official Full Name: heat shock protein family H (Hsp110) member 1provided by RGD
Primary source: RGD:1311609
See related: EnsemblRapid:ENSRNOG00000000902 AllianceGenome:RGD:1311609
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hsp105
Summary: Predicted to enable adenyl-nucleotide exchange factor activity and alpha-tubulin binding activity. Predicted to be involved in protein folding. Predicted to act upstream of or within chaperone cofactor-dependent protein refolding. Predicted to be located in cytoplasm; microtubule; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytosol and nucleus. Orthologous to human HSPH1 (heat shock protein family H (Hsp110) member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 213.3), Kidney (RPKM 139.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12p11

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (10427368..10446602)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (5390916..5410224)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (6322685..6341898, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Temporal and spatial changes in Hsp105 expression in pregnant rat uterus has a physiological role in regulating embryo implantation.
Title: Increased expression of heat shock protein 105 in rat uterus of early pregnancy and its significance in embryo implantation.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129540 (e-PCR)
- UniSTS:212842

AI600071 (e-PCR)
- UniSTS:250251

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables adenyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables adenyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables alpha-tubulin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chaperone cofactor-dependent protein refolding	ISO Inferred from Sequence Orthology more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: heat shock protein 105 kDa

Names: heat shock 105/110 protein 1; heat shock 105kDa; heat shock 105kDa/110kDa protein 1; heat shock 110 kDa protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011901.2 → NP_001011901.1 heat shock protein 105 kDa

See identical proteins and their annotated locations for NP_001011901.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

Q66HA8

UniProtKB/TrEMBL

A0A8I6GLC4, A6K161

Related

ENSRNOP00000001201.6, ENSRNOT00000001201.9

Conserved Domains (1) summary

cd11739
Location:2 → 384

HSPH1_NBD; Nucleotide-binding domain of HSPH1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

10427368..10446602

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039089153.2 → XP_038945081.1 heat shock protein 105 kDa isoform X1

UniProtKB/TrEMBL

A0A8I5ZXF4, A0A8I6GLC4

Related

ENSRNOP00000082622.1, ENSRNOT00000116960.2

Conserved Domains (1) summary

cd11739
Location:2 → 384

HSPH1_NBD; Nucleotide-binding domain of HSPH1
XM_063271115.1 → XP_063127185.1 heat shock protein 105 kDa isoform X2