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    Arfgap1 ARF GTPase activating protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246310, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Arfgap1provided by RGD
    Official Full Name
    ARF GTPase activating protein 1provided by RGD
    Primary source
    RGD:708452
    See related
    EnsemblRapid:ENSRNOG00000043150 AllianceGenome:RGD:708452
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Arf1gap; Arf GAP1
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in regulation of ARF protein signal transduction and regulation of endocytosis. Located in Golgi membrane. Orthologous to human ARFGAP1 (ADP ribosylation factor GTPase activating protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 153.2), Muscle (RPKM 148.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arfgap1 in Genome Data Viewer
    Location:
    3q43
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (188462125..188477515)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (168084560..168099948)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (176475847..176490642)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene baculoviral IAP repeat-containing 7 Neighboring gene Sodium/potassium transporting ATPase interacting 4 Neighboring gene collagen type XX alpha 1 chain Neighboring gene cholinergic receptor nicotinic alpha 4 subunit Neighboring gene potassium voltage-gated channel subfamily Q member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ArfGAP1 interacts with coat proteins through tryptophan-based motifs. Rawet M, et al. Biochem Biophys Res Commun, 2010 Apr 9. PMID 20211604
    2. Two lipid-packing sensor motifs contribute to the sensitivity of ArfGAP1 to membrane curvature. Mesmin B, et al. Biochemistry, 2007 Feb 20. PMID 17253781
    3. ADP-ribosylation factor-directed GTPase-activating protein. Purification and partial characterization. Makler V, et al. J Biol Chem, 1995 Mar 10. PMID 7890632
    4. Golgi localization determinants in ArfGAP1 and in new tissue-specific ArfGAP1 isoforms. Parnis A, et al. J Biol Chem, 2006 Feb 17. PMID 16316994
    5. Sorting of Golgi resident proteins into different subpopulations of COPI vesicles: a role for ArfGAP1. Lanoix J, et al. J Cell Biol, 2001 Dec 24. PMID 11748249, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these findings point to mechanistic differences between ArfGAP1 and the other ArfGAPs known to function in the COPI system.
      Title: ArfGAP1 interacts with coat proteins through tryptophan-based motifs.
    2. Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking
      Title: Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking.
    3. ALPS1 is the primary determinant of the interaction of ArfGAP1 with lipid membranes and that ALPS2 reinforces this interaction 40-fold; ArfGAP1 responds to a wide range of membrane curvature and adapts to lipid membranes of various acyl chain compositions
      Title: Two lipid-packing sensor motifs contribute to the sensitivity of ArfGAP1 to membrane curvature.
    4. Data show that casein kinase I is required for protein traffic through the early secretory pathway and can modulate the amount of ADP-ribosylation factor-GTPase activating protein (ARF-GAP1) that can bind to membranes.
      Title: Casein kinase I regulates membrane binding by ARF GAP1.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of ARF protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribosylation factor GTPase-activating protein 1
    Names
    ADP-ribosylation factor 1 GTPase-activating protein
    ADP-ribosylation factor GTPase activating protein 1
    ARF GAP 1
    ARF1 GAP
    ARF1-directed GTPase-activating protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145090.4 → NP_659558.1  ADP-ribosylation factor GTPase-activating protein 1

      See identical proteins and their annotated locations for NP_659558.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q62848
      UniProtKB/TrEMBL
      A0A0H2UHZ3, A6KM64
      Conserved Domains (1) summary
      cd08830
      Location:6 → 121
      ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      188462125..188477515
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235732.4 → XP_006235794.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006235794.1

      UniProtKB/TrEMBL
      A0A0H2UHZ3, Q3S4A4
      Related
      ENSRNOP00000013900.5, ENSRNOT00000013900.8
      Conserved Domains (2) summary
      pfam01412
      Location:7 → 114
      ArfGap; Putative GTPase activating protein for Arf
      pfam13257
      Location:325 → 376
      DUF4048; Domain of unknown function (DUF4048)

    2. XM_063283084.1 → XP_063139154.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X3

    3. XM_063283085.1 → XP_063139155.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X4

      UniProtKB/TrEMBL
      Q3S4A5

    4. XM_063283087.1 → XP_063139157.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X5

      Related
      ENSRNOP00000073451.2, ENSRNOT00000082267.3

    5. XM_063283089.1 → XP_063139159.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X6

    6. XM_006235731.4 → XP_006235793.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006235793.1

      UniProtKB/TrEMBL
      A0A0H2UHZ3, Q3S4A4
      Conserved Domains (2) summary
      pfam01412
      Location:7 → 114
      ArfGap; Putative GTPase activating protein for Arf
      pfam13257
      Location:325 → 376
      DUF4048; Domain of unknown function (DUF4048)

    7. XM_063283086.1 → XP_063139156.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X4

      UniProtKB/TrEMBL
      Q3S4A5

    8. XM_063283088.1 → XP_063139158.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X5

    9. XM_063283090.1 → XP_063139160.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X6

    10. XM_039104259.2 → XP_038960187.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q62848
      UniProtKB/TrEMBL
      A0A0H2UHZ3, A6KM64
      Related
      ENSRNOP00000051916.5, ENSRNOT00000055038.5
      Conserved Domains (1) summary
      cd08830
      Location:6 → 121
      ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

    11. XM_063283091.1 → XP_063139161.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X7

    RNA

    1. XR_010064557.1 RNA Sequence

    2. XR_010064559.1 RNA Sequence

    3. XR_010064560.1 RNA Sequence

    4. XR_010064558.1 RNA Sequence

    5. XR_010064561.1 RNA Sequence

    6. XR_010064562.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62848.1 GenPept UniProtKB/Swiss-Prot:Q62848

    Gene LinkOut

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