Fcer2 Fc epsilon receptor II [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fcer2provided by RGD
Official Full Name: Fc epsilon receptor IIprovided by RGD
Primary source: RGD:619997
See related: EnsemblRapid:ENSRNOG00000001005 AllianceGenome:RGD:619997
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CD23; Fcer2a
Summary: Predicted to enable several functions, including IgE binding activity; low-affinity IgE receptor activity; and protease binding activity. Predicted to be involved in several processes, including Fc receptor-mediated immune complex endocytosis; positive regulation of nitric-oxide synthase activity; and positive regulation of nitric-oxide synthase biosynthetic process. Predicted to act upstream of or within positive regulation of humoral immune response mediated by circulating immunoglobulin. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Orthologous to human FCER2 (Fc epsilon receptor II). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 57.4), Heart (RPKM 28.3) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12p12

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (6540697..6552364, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (1742809..1754476, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (2233772..2245324, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Immunohistochemical analyses suggested that the Fcalpha/muR isoform was expressed in the tubular epithelial cells, but not in the glomeruli.
Title: Identification of the Fcalpha/muR isoform specifically expressed in the kidney tubules.
These data suggest that IgE and CD23/NO could play an important role in the resistance of adult rats experiencing Plasmoidum berghei Anka primary intraerythrocytic development.
Title: A role of IgE and CD23/NO immune pathway in age-related resistance of Lewis rats to Plasmodium berghei Anka?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables IgE binding	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	IBA Inferred from Biological aspect of Ancestor more info
enables low-affinity IgE receptor activity	ISO Inferred from Sequence Orthology more info
enables pattern recognition receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protease binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell antigen processing and presentation	ISO Inferred from Sequence Orthology more info
involved_in Fc receptor-mediated immune complex endocytosis	ISO Inferred from Sequence Orthology more info
involved_in Fc-epsilon receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Fc-gamma receptor signaling pathway involved in phagocytosis	IEA Inferred from Electronic Annotation more info
involved_in Fc-gamma receptor signaling pathway involved in phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in macrophage activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of humoral immune response mediated by circulating immunoglobulin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric-oxide synthase activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: low affinity immunoglobulin epsilon Fc receptor

Names: Fc fragment of IgE receptor II; Fc fragment of IgE, low affinity II, receptor for (CD23); Fc receptor alpha multiple ligand receptor; Fc receptor, IgE, low affinity II, alpha polypeptide; Fcalpha RII; Fcalpha muR

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033924.1 → NP_001029096.1 low affinity immunoglobulin epsilon Fc receptor isoform a

Status: VALIDATED

Source sequence(s)

BC078749

UniProtKB/TrEMBL

F7EKM2, Q6AZ45, Q8R4T3

Related

ENSRNOP00000001332.4, ENSRNOT00000001332.8

Conserved Domains (2) summary

cd03590
Location:186 → 306

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

cl23720
Location:60 → 170

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_133550.2 → NP_598234.2 low affinity immunoglobulin epsilon Fc receptor isoform b

Status: VALIDATED

Source sequence(s)

BC078749, X73579

UniProtKB/TrEMBL

A6KQ36, Q63097

Related

ENSRNOP00000085732.2, ENSRNOT00000102279.2

Conserved Domains (2) summary

cd03590
Location:165 → 285

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

cl23720
Location:67 → 149

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)