Sycp3 synaptonemal complex protein 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Sycp3provided by RGD
Full Name: synaptonemal complex protein 3provided by RGD
Primary source: RGD:3795
See related: EnsemblRapid:ENSRNOG00000005270 AllianceGenome:RGD:3795
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RNASCP3
Summary: Predicted to enable DNA binding activity. Predicted to be involved in female meiosis chromosome segregation; female meiosis sister chromatid cohesion; and spermatid development. Predicted to act upstream of or within several processes, including cellular response to leukemia inhibitory factor; meiosis I cell cycle process; and sperm DNA condensation. Located in lateral element. Human ortholog(s) of this gene implicated in spermatogenic failure 4. Orthologous to human SYCP3 (synaptonemal complex protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 603.2), Kidney (RPKM 186.0) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q13

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (24761476..24775933)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (22874055..22888512)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (29029887..29044344)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Unlike other vertebrates, rat and mouse SYCP3 exists in 2 isoforms; the short isoform is conserved in vertebrates and the longer isoform, appeared 15 million years ago in a common ancestor of rat and mouse and after separation from the hamster branch.
Title: Synaptonemal complex protein SYCP3 exists in two isoforms showing different conservation in mammalian evolution.
The possible contribution of different SYCP3 domains to the assembly of higher order structures, is investigated.
Title: Synaptonemal complex protein SYCP3 of the rat: evolutionarily conserved domains and the assembly of higher order structures.

Submit: New GeneRIF Correction

General gene information

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Markers

mScp3 (e-PCR)
- UniSTS:514592

Sycp3 (e-PCR), detects polymorphism
- UniSTS:461899

Sycp3 (e-PCR), detects polymorphism
- UniSTS:471180

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chiasma assembly	ISO Inferred from Sequence Orthology more info
involved_in chiasma assembly	ISO Inferred from Sequence Orthology more info
involved_in female meiosis chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in female meiosis sister chromatid cohesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within homologous chromosome pairing at meiosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lateral element assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within meiotic DNA repair synthesis	ISO Inferred from Sequence Orthology more info
involved_in meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within meiotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sperm DNA condensation	ISO Inferred from Sequence Orthology more info
involved_in sperm DNA condensation	ISO Inferred from Sequence Orthology more info
involved_in spermatid development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synaptonemal complex assembly	ISO Inferred from Sequence Orthology more info
involved_in synaptonemal complex assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
located_in chromosome, centromeric region	ISS Inferred from Sequence or Structural Similarity more info
located_in condensed chromosome	ISO Inferred from Sequence Orthology more info
located_in condensed chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
located_in condensed nuclear chromosome	ISO Inferred from Sequence Orthology more info
located_in female germ cell nucleus	ISO Inferred from Sequence Orthology more info
located_in lateral element	IDA Inferred from Direct Assay more info	PubMed
located_in lateral element	ISO Inferred from Sequence Orthology more info
located_in male germ cell nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in synaptonemal complex	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptonemal complex	ISO Inferred from Sequence Orthology more info
located_in transverse filament	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: synaptonemal complex protein 3

Names: SCP-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.