Arpc2 Actin-related protein 2/3 complex, subunit 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Arpc2provided by FlyBase
Official Full Name: Actin-related protein 2/3 complex, subunit 2provided by FlyBase
Primary source: FLYBASE:FBgn0032859
Locus tag: Dmel_CG10954
See related: AllianceGenome:FB:FBgn0032859
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 38C.47; anon-WO0118547.154; Arc-p34; ARC-p34; ARC-P34; Arc-p34/Arpc2; ArcP34; arpC2; ARPC2; ARPC2/p34; CG10954; Dmel\CG10954; p34
Summary: Predicted to enable actin filament binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in cell projection assembly; cortical actin cytoskeleton organization; and regulation of cell shape. Located in apical cortex. Colocalizes with contractile ring. Is expressed in several structures, including adult brain cell body rind; adult head; embryonic/larval midgut; and synaptic neuropil domain. Orthologous to human ARPC2 (actin related protein 2/3 complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (20417057..20423027)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (20417057..20423027)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

The Arp2/3 complex and the formin, Diaphanous, are both required to regulate the size of germline ring canals in the developing egg chamber.
Title: The Arp2/3 complex and the formin, Diaphanous, are both required to regulate the size of germline ring canals in the developing egg chamber.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in Arp2/3 complex-mediated actin nucleation	IEA Inferred from Electronic Annotation more info
involved_in Arp2/3 complex-mediated actin nucleation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in actin filament polymerization	IEA Inferred from Electronic Annotation more info
involved_in cell projection assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cortical actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Arp2/3 protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Arp2/3 protein complex	IEA Inferred from Electronic Annotation more info
part_of Arp2/3 protein complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in apical cortex	HDA more info	PubMed
colocalizes_with contractile ring	HDA more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain