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    tweek tweek [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35026, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tweekprovided by FlyBase
    Official Full Name
    tweekprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261671
    Locus tag
    Dmel_CG42555
    See related
    AllianceGenome:FB:FBgn0261671
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15133; CG15134; CG42555; CG42706; CG4841; Dmel\CG42555; Tweek
    Old locus tag
    Dmel_CG15133; Dmel_CG15134; Dmel_CG4841
    Summary
    Involved in regulation of synaptic vesicle endocytosis and synaptic vesicle endocytosis. Is active in neuromuscular junction. Is expressed in adult head; embryonic hindgut; embryonic/larval midgut primordium; ganglia; and spermatozoon. Human ortholog(s) of this gene implicated in Alkuraya-Kucinskas syndrome. Orthologous to human BLTP1 (bridge-like lipid transfer protein family member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tweek in Genome Data Viewer
    Location:
    36B3-36B4; 2-53 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16888490..16917052)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16888490..16917052)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44392 Neighboring gene uncharacterized protein Neighboring gene orsai Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Aminopeptidase P Neighboring gene long non-coding RNA:CR43053 Neighboring gene long non-coding RNA:CR44393

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterizing dopaminergic neuron vulnerability using genome-wide analysis. Davis J, et al. Genetics, 2021 Aug 9. PMID 34038543, Free PMC Article
    2. Proteomic analysis reveals APC-dependent post-translational modifications and identifies a novel regulator of β-catenin. Blundon MA, et al. Development, 2016 Jul 15. PMID 27287809, Free PMC Article
    3. WASP is activated by phosphatidylinositol-4,5-bisphosphate to restrict synapse growth in a pathway parallel to bone morphogenetic protein signaling. Khuong TM, et al. Proc Natl Acad Sci U S A, 2010 Oct 5. PMID 20844206, Free PMC Article
    4. Tweek, an evolutionarily conserved protein, is required for synaptic vesicle recycling. Verstreken P, et al. Neuron, 2009 Jul 30. PMID 19640479, Free PMC Article
    5. Toxicological Study and Genetic Basis of BTEX Susceptibility in Drosophila melanogaster. Adebambo TH, et al. Front Genet, 2020. PMID 33193742, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of synaptic vesicle endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tweek
    Names
    CG42555-PF
    CG42555-PG
    CG42555-PH
    CG42555-PI
    CG42555-PJ
    CG42555-PK
    tweek-PF
    tweek-PG
    tweek-PH
    tweek-PI
    tweek-PJ
    tweek-PK

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16888490..16917052
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299073.1 → NP_001286002.1  tweek, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286002.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JA38
      Conserved Domains (1) summary
      pfam10479
      Location:4415 → 5113
      FSA_C; Fragile site-associated protein C-terminus

    2. NM_001299074.1 → NP_001286003.1  tweek, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286003.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JAP2
      Conserved Domains (1) summary
      pfam10479
      Location:4381 → 5073
      FSA_C; Fragile site-associated protein C-terminus

    3. NM_001201897.2 → NP_001188826.2  tweek, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188826.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRK7
      Conserved Domains (1) summary
      pfam10479
      Location:4387 → 5079
      FSA_C; Fragile site-associated protein C-terminus

    4. NM_001201895.2 → NP_001188824.2  tweek, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188824.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRV1
      Conserved Domains (1) summary
      pfam10479
      Location:4367 → 5059
      FSA_C; Fragile site-associated protein C-terminus

    5. NM_001201896.2 → NP_001188825.2  tweek, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188825.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRP6
      Conserved Domains (1) summary
      pfam10479
      Location:4366 → 5058
      FSA_C; Fragile site-associated protein C-terminus

    6. NM_001201898.2 → NP_001188827.2  tweek, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188827.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSI8
      Conserved Domains (1) summary
      pfam10479
      Location:4346 → 5038
      FSA_C; Fragile site-associated protein C-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MRK7 M9MRK7
    M9MRP6 M9MRP6
    M9MRV1 M9MRV1
    M9MSI8 M9MSI8
    Q8T620 Q8T620
    X2JA38 X2JA38
    X2JAP2 X2JAP2

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