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    sc scute [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 30982, updated on 9-Dec-2024

    Summary

    Official Symbol
    scprovided by FlyBase
    Official Full Name
    scuteprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004170
    Locus tag
    Dmel_CG3827
    See related
    AllianceGenome:FB:FBgn0004170
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AS-C T4; AS-C T4sc; ascT4; bHLHc28; CG3827; Dmel\CG3827; DROACS2; EG:198A6.1; Hw; l(1)1Ba; Sc; sc/T4; scalpha; Scute; scute/sisterlessB; SC_DA; sis b; sis-b; sisb; sisB; T4; T4 AS-C
    Summary
    Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Contributes to sequence-specific DNA binding activity. Involved in several processes, including Malpighian tubule tip cell differentiation; chaeta morphogenesis; and nervous system development. Part of transcription regulator complex. Is expressed in several structures, including adult mesothoracic sensillum; gut section; neurogenic region; procephalic segment; and somatic precursor cell. Orthologous to several human genes including ASCL1 (achaete-scute family bHLH transcription factor 1); ASCL2 (achaete-scute family bHLH transcription factor 2); and ASCL3 (achaete-scute family bHLH transcription factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    Location:
    1A8-1A8; 1-0 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (396060..397497)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (290093..291530)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44752 Neighboring gene long non-coding RNA:CR44753 Neighboring gene lethal of scute Neighboring gene Pepsinogen C-like

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to sequence-specific DNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Malpighian tubule tip cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in central nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in chaeta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chaeta morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chaeta morphogenesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in enteroendocrine cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nervous system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in neuroblast fate determination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in peripheral nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peripheral nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sensory organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sensory organ development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sex determination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in sex determination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sex determination TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in sex determination, establishment of X:A ratio NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in ventral cord development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    scute
    Names
    Achaete/Scute
    CG3827-PA
    Hairy-wing
    achaete-scute
    asc
    sc-PA
    scute alpha
    scute-T4-transcript
    scute/sisterless-b
    sisterless-b

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      396060..397497
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057455.3NP_476803.1  scute [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476803.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76890, P10084, Q4V705
      Related
      FBpp0070072
      Conserved Domains (1) summary
      pfam00010
      Location:105163
      HLH; Helix-loop-helix DNA-binding domain