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    DIP-beta Dpr-interacting protein beta [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33125, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DIP-betaprovided by FlyBase
    Official Full Name
    Dpr-interacting protein betaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259245
    Locus tag
    Dmel_CG42343
    See related
    AllianceGenome:FB:FBgn0259245
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    42343; BcDNA:RE23430; BP1062; CG12564; CG12565; CG14583; CG34019; CG42343; CT34319; DIPbeta; Dmel\CG42343; pp-CT34319; pp-CT34320; pp-CT34321
    Old locus tag
    Dmel_CG12564; Dmel_CG12565; Dmel_CG14583; Dmel_CG34019
    Summary
    Involved in synapse organization. Predicted to be located in plasma membrane. Predicted to be active in neuron projection. Is expressed in several structures, including CNS glial cell; ganglia; larval nervous system; medulla layer; and optic lobe intrinsic columnar neurons. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to several human genes including IGLON5 (IgLON family member 5); LSAMP (limbic system associated membrane protein); and NTM (neurotrimin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See DIP-beta in Genome Data Viewer
    Location:
    20A1-20A1; 1-66 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (21422115..21457738, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (21293142..21328765, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45003 Neighboring gene what else Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45507 Neighboring gene long non-coding RNA:CR45508

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neural connectivity molecules best identify the heterogeneous clock and dopaminergic cell types in the Drosophila adult brain. Ma D, et al. Sci Adv, 2023 Feb 22. PMID 36812309, Free PMC Article
    2. Control of Synaptic Specificity by Establishing a Relative Preference for Synaptic Partners. Xu C, et al. Neuron, 2019 Sep 4. PMID 31300277, Free PMC Article
    3. Homeodomain proteins hierarchically specify neuronal diversity and synaptic connectivity. Xu C, et al. Elife, 2024 Jan 5. PMID 38180023, Free PMC Article
    4. Stereotyped terminal axon branching of leg motor neurons mediated by IgSF proteins DIP-α and Dpr10. Venkatasubramanian L, et al. Elife, 2019 Feb 4. PMID 30714901, Free PMC Article
    5. Ca2+ and cAMP open differentially dilating synaptic fusion pores. Bulgari D, et al. J Cell Sci, 2023 Jul 1. PMID 37303204, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: c21434462-21434215 mobile_element_type = transposon:INE-1{}6161

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in synapse organization IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Dpr-interacting protein beta
    Names
    CG42343-PC
    CG42343-PD
    CG42343-PE
    CG42343-PF
    CG42343-PG
    DIP-beta-PC
    DIP-beta-PD
    DIP-beta-PE
    DIP-beta-PF
    DIP-beta-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      21422115..21457738 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144754.2 → NP_001138226.1  Dpr-interacting protein beta, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138226.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z153
      Conserved Domains (4) summary
      smart00410
      Location:219 → 307
      IG_like; Immunoglobulin like
      pfam07679
      Location:98 → 209
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:102 → 195
      ig; Immunoglobulin domain
      cl11960
      Location:221 → 307
      Ig; Immunoglobulin domain

    2. NM_001298591.1 → NP_001285520.1  Dpr-interacting protein beta, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285520.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JCW3
      Conserved Domains (2) summary
      smart00410
      Location:95 → 186
      IG_like; Immunoglobulin like
      cl11960
      Location:200 → 286
      Ig; Immunoglobulin domain

    3. NM_001144753.2 → NP_001138225.1  Dpr-interacting protein beta, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138225.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z153
      Conserved Domains (4) summary
      smart00410
      Location:219 → 307
      IG_like; Immunoglobulin like
      pfam07679
      Location:98 → 209
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:102 → 195
      ig; Immunoglobulin domain
      cl11960
      Location:221 → 307
      Ig; Immunoglobulin domain

    4. NM_167755.2 → NP_728431.1  Dpr-interacting protein beta, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728431.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZ18, Q9VRI6
      Related
      FBpp0289178

    5. NM_134611.5 → NP_608455.2  Dpr-interacting protein beta, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608455.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZ18, Q9VRI6
      Related
      FBpp0289177
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z153 B7Z153
    Q9VRI6 Q9VRI6
    X2JCW3 X2JCW3

    Gene LinkOut

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