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    CG1407 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36043, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG1407provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033474
    Locus tag
    Dmel_CG1407
    See related
    AllianceGenome:FB:FBgn0033474
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG1407; ZDHHC15
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in protein targeting to membrane and synaptic vesicle maturation. Located in plasma membrane. Is expressed in adult central nervous system; adult head; larval brain; and organism. Orthologous to several human genes including ZDHHC2 (zinc finger DHHC-type palmitoyltransferase 2) and ZDHHC20 (zinc finger DHHC-type palmitoyltransferase 20). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG1407 in Genome Data Viewer
    Location:
    46D5-46D7; 2-61 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10028443..10032893, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5915948..5920398, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Protein kinase, cAMP-dependent, regulatory subunit type 2 Neighboring gene mir-4967 stem loop Neighboring gene long non-coding RNA:CR44294 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene oysgedart Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutation in ZDHHC15 Leads to Hypotonic Cerebral Palsy, Autism, Epilepsy, and Intellectual Disability. Lewis SA, et al. Neurol Genet, 2021 Aug. PMID 34345675, Free PMC Article
    2. Membrane targeting of inhibitory Smads through palmitoylation controls TGF-β/BMP signaling. Li W, et al. Proc Natl Acad Sci U S A, 2017 Dec 12. PMID 29180412, Free PMC Article
    3. The S-palmitoylome and DHHC-PAT interactome of Drosophila melanogaster S2R+ cells indicate a high degree of conservation to mammalian palmitoylomes. Porcellato E, et al. PLoS One, 2022. PMID 35960718, Free PMC Article
    4. Gain of function screen of PATs reveals an essential role of Hip14 in Drosophila host defense. Deng Z, et al. J Genet Genomics, 2023 Dec. PMID 37343788
    5. Mutations disrupting neuritogenesis genes confer risk for cerebral palsy. Jin SC, et al. Nat Genet, 2020 Oct. PMID 32989326, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG1407-PA
    CG1407-PB
    CG1407-PC
    CG1407-PD
    CG1407-PE
    CG1407-PF
    CG1407-PG
    NP_001260843.1
    NP_001286262.1
    NP_001286263.1
    NP_001286264.1
    NP_610544.1
    NP_724868.2
    NP_724869.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10028443..10032893 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136700.4 → NP_610544.1  uncharacterized protein Dmel_CG1407, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610544.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K2V5
      Related
      FBpp0087521
      Conserved Domains (1) summary
      pfam01529
      Location:129 → 250
      zf-DHHC; DHHC palmitoyltransferase

    2. NM_001273914.2 → NP_001260843.1  uncharacterized protein Dmel_CG1407, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260843.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KF56
      Conserved Domains (1) summary
      pfam01529
      Location:129 → 250
      zf-DHHC; DHHC palmitoyltransferase

    3. NM_001299333.1 → NP_001286262.1  uncharacterized protein Dmel_CG1407, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286262.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LF00
      Conserved Domains (1) summary
      pfam01529
      Location:129 → 247
      zf-DHHC; DHHC palmitoyltransferase

    4. NM_001299334.1 → NP_001286263.1  uncharacterized protein Dmel_CG1407, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286263.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LEL6
      Conserved Domains (1) summary
      pfam01529
      Location:129 → 256
      zf-DHHC; DHHC palmitoyltransferase

    5. NM_165728.4 → NP_724868.2  uncharacterized protein Dmel_CG1407, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724868.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z833
      Related
      FBpp0087522
      Conserved Domains (1) summary
      pfam01529
      Location:129 → 250
      zf-DHHC; DHHC palmitoyltransferase

    6. NM_001299335.1 → NP_001286264.1  uncharacterized protein Dmel_CG1407, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286264.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LF16
      Conserved Domains (1) summary
      pfam01529
      Location:129 → 259
      zf-DHHC; DHHC palmitoyltransferase

    7. NM_165729.3 → NP_724869.2  uncharacterized protein Dmel_CG1407, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724869.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E2QCN5
      Conserved Domains (1) summary
      pfam01529
      Location:129 → 200
      zf-DHHC; DHHC palmitoyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KF56 A0A0B4KF56
    A0A0B4LEL6 A0A0B4LEL6
    A0A0B4LF00 A0A0B4LF00
    A0A0B4LF16 A0A0B4LF16
    A1Z833 A1Z833
    E2QCN5 E2QCN5
    Q7K2V5 Q7K2V5
    Q960T3 Q960T3

    Gene LinkOut

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