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    ApepP Aminopeptidase P [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35029, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ApepPprovided by FlyBase
    Official Full Name
    Aminopeptidase Pprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026150
    Locus tag
    Dmel_CG6291
    See related
    AllianceGenome:FB:FBgn0026150
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AP-P; Apep[P]; CG6291; Daminopep-p; DAP-P; Dmel\CG6291
    Summary
    Enables metalloaminopeptidase activity. Involved in proteolysis. Located in cytosol. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval crystal cell; embryonic/larval midgut primordium; and posterior endoderm. Orthologous to human XPNPEP1 (X-prolyl aminopeptidase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ApepP in Genome Data Viewer
    Location:
    36B4-36B4; 2-53 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16908229..16910418, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16908229..16910418, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene tweek Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43053 Neighboring gene long non-coding RNA:CR44393

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A cytosolic form of aminopeptidase P from Drosophila melanogaster: molecular cloning and characterization. Kulkarni GV, et al. J Biochem, 2002 Mar. PMID 11872174
    2. Proteomic analysis reveals APC-dependent post-translational modifications and identifies a novel regulator of β-catenin. Blundon MA, et al. Development, 2016 Jul 15. PMID 27287809, Free PMC Article
    3. Comparison of embryonic expression within multigene families using the FlyExpress discovery platform reveals more spatial than temporal divergence. Konikoff CE, et al. Dev Dyn, 2012 Jan. PMID 21960044, Free PMC Article
    4. Tweek, an evolutionarily conserved protein, is required for synaptic vesicle recycling. Verstreken P, et al. Neuron, 2009 Jul 30. PMID 19640479, Free PMC Article
    5. Base Editing of Somatic Cells Using CRISPR-Cas9 in Drosophila. Marr E, et al. CRISPR J, 2021 Dec. PMID 34813372, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metalloaminopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aminopeptidase P
    Names
    ApepP-PA
    ApepP-PB
    CG6291-PA
    CG6291-PB
    NP_001246053.1
    NP_477409.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16908229..16910418 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058061.5 → NP_477409.1  aminopeptidase P, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477409.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VJG0
      UniProtKB/TrEMBL
      O96794
      Related
      FBpp0080509
      Conserved Domains (4) summary
      cd01085
      Location:321 → 545
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam01321
      Location:9 → 154
      Creatinase_N; Creatinase/Prolidase N-terminal domain
      pfam16188
      Location:551 → 613
      Peptidase_M24_C; C-terminal region of peptidase_M24
      pfam16189
      Location:158 → 318
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain

    2. NM_001259124.2 → NP_001246053.1  aminopeptidase P, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246053.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VJG0
      UniProtKB/TrEMBL
      O96794
      Conserved Domains (4) summary
      cd01085
      Location:321 → 545
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam01321
      Location:9 → 154
      Creatinase_N; Creatinase/Prolidase N-terminal domain
      pfam16188
      Location:551 → 613
      Peptidase_M24_C; C-terminal region of peptidase_M24
      pfam16189
      Location:158 → 318
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O96794 O96794
    Q9VJG0.1 Q9VJG0

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