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    CG44422 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32063, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG44422provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0265595
    Locus tag
    Dmel_CG44422
    See related
    AllianceGenome:FB:FBgn0265595
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11105; CG12625; CG34144; CG42683; Dmel\CG44422; Dm_X:57642
    Old locus tag
    Dmel_CG11105; Dmel_CG12625; Dmel_CG34144; Dmel_CG42683
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in regulation of signal transduction. Is expressed in adult head. Orthologous to human KCNIP1 (potassium voltage-gated channel interacting protein 1) and KCNIP4 (potassium voltage-gated channel interacting protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG44422 in Genome Data Viewer
    Location:
    10B1-10B2; 1-34 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11219379..11302783, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11113412..11196816, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44765 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ionotropic receptor 10a Neighboring gene sisterless A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular evolution and population genetic analysis of candidate female reproductive genes in Drosophila. Panhuis TM, et al. Genetics, 2006 Aug. PMID 16783023, Free PMC Article
    2. Stress response, behavior, and development are shaped by transposable element-induced mutations in Drosophila. Rech GE, et al. PLoS Genet, 2019 Feb. PMID 30753202, Free PMC Article
    3. Retroactive, a membrane-anchored extracellular protein related to vertebrate snake neurotoxin-like proteins, is required for cuticle organization in the larva of Drosophila melanogaster. Moussian B, et al. Dev Dyn, 2005 Jul. PMID 15844167
    4. Epi-MEIF: detecting higher order epistatic interactions for complex traits using mixed effect conditional inference forests. Saha S, et al. Nucleic Acids Res, 2022 Oct 28. PMID 36107776, Free PMC Article
    5. Identification of genes expressed during Drosophila melanogaster gastrulation by using subtractive hybridization. González-Agüero M, et al. Gene, 2005 Jan 31. PMID 15716118

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG44422-PA
    CG44422-PB
    CG44422-PC
    CG44422-PD
    CG44422-PE
    CG44422-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11219379..11302783 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272515.2 → NP_001259444.1  uncharacterized protein Dmel_CG44422, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259444.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEA8
      Conserved Domains (2) summary
      COG5126
      Location:254 → 422
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:349 → 421
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    2. NM_001201649.4 → NP_001188578.1  uncharacterized protein Dmel_CG44422, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188578.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MS47
      Conserved Domains (2) summary
      COG5126
      Location:254 → 419
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:346 → 418
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    3. NM_167277.2 → NP_727507.2  uncharacterized protein Dmel_CG44422, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727507.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A023GPJ1
      Conserved Domains (2) summary
      COG5126
      Location:181 → 346
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:273 → 345
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    4. NM_132471.5 → NP_572699.2  uncharacterized protein Dmel_CG44422, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572699.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IR92
      Conserved Domains (2) summary
      COG5126
      Location:254 → 419
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:346 → 418
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    5. NM_001298188.1 → NP_001285117.1  uncharacterized protein Dmel_CG44422, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285117.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JJG0
      Conserved Domains (2) summary
      COG5126
      Location:181 → 346
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:273 → 345
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    6. NM_132472.4 → NP_572700.2  uncharacterized protein Dmel_CG44422, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572700.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZ13
      Conserved Domains (2) summary
      COG5126
      Location:268 → 433
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:360 → 432
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A023GPJ1 A0A023GPJ1
    M9MS47 M9MS47
    M9PEA8 M9PEA8
    Q8IR92 Q8IR92
    Q9VZ13 Q9VZ13
    X2JJG0 X2JJG0

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