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    CG43125 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 12798281, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG43125provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262588
    Locus tag
    Dmel_CG43125
    See related
    AllianceGenome:FB:FBgn0262588
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG43125; SPH250
    Summary
    Predicted to be involved in innate immune response. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG43125 in Genome Data Viewer
    Location:
    98C3-98C3; 3-95 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (28262735..28263622, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24088457..24089344, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46079 Neighboring gene long non-coding RNA:CR46080 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45041 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Forcing contacts between mitochondria and the endoplasmic reticulum extends lifespan in a Drosophila model of Alzheimer's disease. Garrido-Maraver J, et al. Biol Open, 2020 Jan 14. PMID 31822473, Free PMC Article
    2. Beneficial commensal bacteria promote Drosophila growth by downregulating the expression of peptidoglycan recognition proteins. Gallo M, et al. iScience, 2022 Jun 17. PMID 35601912, Free PMC Article
    3. The evolution of constitutively active humoral immune defenses in Drosophila populations under high parasite pressure. Zhou SO, et al. PLoS Pathog, 2024 Jan. PMID 38206983, Free PMC Article
    4. Inter- and intra-species variation in genome-wide gene expression of Drosophila in response to parasitoid wasp attack. Salazar-Jaramillo L, et al. BMC Genomics, 2017 Apr 27. PMID 28449654, Free PMC Article
    5. Building a platform for predicting functions of serine protease-related proteins in Drosophila melanogaster and other insects. Cao X, et al. Insect Biochem Mol Biol, 2018 Dec. PMID 30367934, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  
    NOT enables serine-type endopeptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG43125-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      28262735..28263622 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260415.1 → NP_001247344.1  uncharacterized protein Dmel_CG43125 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247344.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7A7
      Conserved Domains (1) summary
      cl21584
      Location:37 → 137
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K7A7 A0A0B4K7A7

    Gene LinkOut

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