WRNexo WRN exonuclease [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: WRNexoprovided by FlyBase
Official Full Name: WRN exonucleaseprovided by FlyBase
Primary source: FLYBASE:FBgn0038608
Locus tag: Dmel_CG7670
See related: AllianceGenome:FB:FBgn0038608
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7670; Dmel\CG7670; DmWRNexo; Wrnexo
Summary: Enables double-stranded DNA 3'-5' DNA exonuclease activity and single-stranded DNA 3'-5' DNA exonuclease activity. Involved in negative regulation of mitotic recombination. Located in nucleus. Is expressed in several structures, including CNS glial cell; central brain primordium; embryonic/larval midgut primordium; ganglia; and gut section. Used to study Werner syndrome. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 91A3-91A3; 3-63 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (18364244..18366162, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (14189966..14191884, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Characterization of Stress Responses in a Drosophila Model of Werner Syndrome.
Title: Characterization of Stress Responses in a Drosophila Model of Werner Syndrome.
WRNexo is important for recovery following both endogenous and exogenous replication stress; the critical role of WRNexo during replication stress does not depend on exonuclease activity
Title: The Drosophila Werner exonuclease participates in an exonuclease-independent response to replication stress.
DmWRNexo is a 3'-5' exonuclease: phenotypic and biochemical characterization of mutants of the Drosophila orthologue of human WRN exonuclease.
Title: DmWRNexo is a 3'-5' exonuclease: phenotypic and biochemical characterization of mutants of the Drosophila orthologue of human WRN exonuclease.
The Drosophila WRN ortholog demonstrates an important role for WRN exonuclease in maintaining genome stability.
Title: Identification and characterization of a Drosophila ortholog of WRN exonuclease that is required to maintain genome integrity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables 3'-5' exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3'-5' exonuclease activity	IEA Inferred from Electronic Annotation more info
enables 3'-5' exonuclease activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables 3'-5' exonuclease activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables double-stranded DNA 3'-5' DNA exonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA 3'-5' DNA exonuclease activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of mitotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleobase-containing compound metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: WRN exonuclease

Names: CG7670-PA; CG7670-PB; CG7670-PC; WRNexo-PA; WRNexo-PB; WRNexo-PC

NP_001163646.1

EC 3.1.11.1

EC 3.1.11.2

NP_001287389.1

EC 3.1.11.1

EC 3.1.11.2

NP_650715.3

EC 3.1.11.1

EC 3.1.11.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

18364244..18366162 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001300460.1 → NP_001287389.1 WRN exonuclease, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287389.1

Status: REVIEWED

UniProtKB/TrEMBL

E8NH59

Conserved Domains (1) summary

cd06141
Location:141 → 313

WRN_exo; DEDDy 3'-5' exonuclease domain of WRN and similar proteins
NM_142458.4 → NP_650715.3 WRN exonuclease, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_650715.3

Status: REVIEWED

UniProtKB/Swiss-Prot

A7L742, B6IDR2, Q961E1, Q9VE86

Related

FBpp0083007

Conserved Domains (1) summary

cd06141
Location:141 → 313

WRN_exo; DEDDy 3'-5' exonuclease domain of WRN and similar proteins
NM_001170175.2 → NP_001163646.1 WRN exonuclease, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163646.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JIP3

Conserved Domains (1) summary

cd06141
Location:142 → 314

WRN_exo; DEDDy 3'-5' exonuclease domain of WRN and similar proteins