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    APC10 Anaphase Promoting Complex subunit 10 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36975, updated on 9-Dec-2024

    Summary

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    Official Symbol
    APC10provided by FlyBase
    Official Full Name
    Anaphase Promoting Complex subunit 10provided by FlyBase
    Primary source
    FLYBASE:FBgn0034231
    Locus tag
    Dmel_CG11419
    See related
    AllianceGenome:FB:FBgn0034231
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Apc10; CG11419; Dmel\CG11419
    Summary
    Involved in endomitotic cell cycle and regulation of stem cell differentiation. Predicted to be part of anaphase-promoting complex. Is expressed in organism. Orthologous to human ANAPC10 (anaphase promoting complex subunit 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See APC10 in Genome Data Viewer
    Location:
    54C1-54C1; 2-83 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17517261..17518186, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13404766..13405691, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Cathepsin K2 Neighboring gene uncharacterized protein Neighboring gene patronin Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 3 subunit b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The E3-ligases SCFPpa and APC/CCdh1 co-operate to regulate CENP-ACID expression across the cell cycle. Moreno-Moreno O, et al. Nucleic Acids Res, 2019 Apr 23. PMID 30753559, Free PMC Article
    2. Whole-animal genome-wide RNAi screen identifies networks regulating male germline stem cells in Drosophila. Liu Y, et al. Nat Commun, 2016 Aug 3. PMID 27484291, Free PMC Article
    3. APC/CFzr/Cdh1 promotes cell cycle progression during the Drosophila endocycle. Narbonne-Reveau K, et al. Development, 2008 Apr. PMID 18321983
    4. The anaphase-promoting complex: it's not just for mitosis any more. Harper JW, et al. Genes Dev, 2002 Sep 1. PMID 12208841
    5. The anaphase-promoting complex/cyclosome: APC/C. Acquaviva C, et al. J Cell Sci, 2006 Jun 15. PMID 16763193

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endomitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic cell cycle HMP PubMed 
    involved_in protein K11-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    anaphase promoting complex subunit 10
    Names
    APC10-PA
    CG11419-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17517261..17518186 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137379.5 → NP_611223.4  anaphase promoting complex subunit 10 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611223.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MTU6, Q9V831
      Related
      FBpp0086107
      Conserved Domains (1) summary
      pfam03256
      Location:10 → 193
      ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V831.2 Q9V831

    Gene LinkOut

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