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    Rh5 Rhodopsin 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34615, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rh5provided by FlyBase
    Official Full Name
    Rhodopsin 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0014019
    Locus tag
    Dmel_CG5279
    See related
    AllianceGenome:FB:FBgn0014019
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5279; Dm Rh5; DMELRH5; Dmel\CG5279; r5; Rh; rh5; RH5
    Summary
    Enables G protein-coupled photoreceptor activity. Involved in several processes, including detection of light stimulus; entrainment of circadian clock by photoperiod; and thermotaxis. Is active in rhabdomere. Is expressed in Bolwig nerve; abdominal ventral campaniform sensillum vc5; adult head; photoreceptor; and photoreceptor neurons. Used to study sensorineural hearing loss. Orthologous to human OPN4 (opsin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rh5 in Genome Data Viewer
    Location:
    33B8-33B8; 2-45 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12008153..12009832)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12008153..12009832)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene transcriptional Adaptor 1-1 Neighboring gene uncharacterized protein Neighboring gene Nfs1 cysteine desulfurase Neighboring gene 3-hydroxyacyl-CoA dehydratase 1 Neighboring gene long non-coding RNA:CR44588 Neighboring gene WD repeat domain 81

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Circuit analysis reveals a neural pathway for light avoidance in Drosophila larvae. Sorkaç A, et al. Nat Commun, 2022 Sep 7. PMID 36071059, Free PMC Article
    2. Age- and Wavelength-Dependency of Drosophila Larval Phototaxis and Behavioral Responses to Natural Lighting Conditions. Humberg TH, et al. Front Behav Neurosci, 2017. PMID 28473759, Free PMC Article
    3. Synaptic targets of photoreceptors specialized to detect color and skylight polarization in Drosophila. Kind E, et al. Elife, 2021 Dec 16. PMID 34913436, Free PMC Article
    4. Identification of a novel Drosophila opsin reveals specific patterning of the R7 and R8 photoreceptor cells. Chou WH, et al. Neuron, 1996 Dec. PMID 8982159
    5. Common transcriptional mechanisms for visual photoreceptor cell differentiation among Pancrustaceans. Mahato S, et al. PLoS Genet, 2014 Jul. PMID 24991928, Free PMC Article

    See all (226) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rh5 and Rh6 were required in trpA1-expressing neurons in the brain, ventral nerve cord, and body wall. Because Rh1 contributes to thermal selection in the comfortable range during the early to mid-third-instar stage, fine thermal discrimination depends on multiple rhodopsins.
      Title: A Switch in Thermal Preference in Drosophila Larvae Depends on Multiple Rhodopsins.
    2. Light reception mediated by Rh5 and Rh6 must utilize either a different (nonretinal) phospholipase C-beta enzyme or alternative signaling mechanisms, at least in terms of clock-relevant photoreception
      Title: Rhodopsin 5- and Rhodopsin 6-mediated clock synchronization in Drosophila melanogaster is independent of retinal phospholipase C-β signaling.
    3. during metamorphosis, all Rh6 photoreceptors die, whereas the Rh5 photoreceptors switch fate by turning off Rh5 and then turning on Rh6 expression
      Title: Switch of rhodopsin expression in terminally differentiated Drosophila sensory neurons.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled photoreceptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled photoreceptor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables G protein-coupled photoreceptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables G protein-coupled photoreceptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UV-A, blue light phototransduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in absorption of visible light IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to light stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in entrainment of circadian clock by photoperiod IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phototransduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phototransduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phototransduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in phototransduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in response to light stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in thermotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in rhabdomere IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rhodopsin 5
    Names
    CG5279-PA
    CG5279-PB
    Rh5-PA
    Rh5-PB
    Rhodopsin5
    rhodopsin
    rhodopsin-5

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      12008153..12009832
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298930.1 → NP_001285859.1  rhodopsin 5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285859.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91657, P91671, Q9VKD1
      UniProtKB/TrEMBL
      X2J5R5
      Conserved Domains (2) summary
      pfam00001
      Location:69 → 332
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:60 → 236
      7tm_4; Olfactory receptor

    2. NM_057748.5 → NP_477096.1  rhodopsin 5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477096.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91657, P91671, Q9VKD1
      UniProtKB/TrEMBL
      X2J5R5
      Related
      FBpp0079875
      Conserved Domains (2) summary
      pfam00001
      Location:69 → 332
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:60 → 236
      7tm_4; Olfactory receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P91657.1 P91657
    X2J5R5 X2J5R5

    Gene LinkOut

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