Pdp Pyruvate dehydrogenase phosphatase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pdpprovided by FlyBase
Official Full Name: Pyruvate dehydrogenase phosphataseprovided by FlyBase
Primary source: FLYBASE:FBgn0029958
Locus tag: Dmel_CG12151
See related: AllianceGenome:FB:FBgn0029958
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 153332_at; CG12151; Dmel\CG12151; pdp; PDP
Summary: Enables phosphoprotein phosphatase activity. Predicted to be involved in signal transduction. Located in mitochondrion and nucleus. Is expressed in several structures, including adult heart; dorsal pharyngeal muscle primordium; embryonic/larval midgut primordium; larval muscle cell; and visceral muscle primordium. Human ortholog(s) of this gene implicated in obesity and pyruvate decarboxylase deficiency. Orthologous to human PDP1 (pyruvate dehydrogenase phosphatase catalytic subunit 1) and PDP2 (pyruvate dehydrogenase phosphatase catalytic subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 7B7-7B7; 1-20 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (7731779..7734651, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (7625812..7628684, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphoprotein phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of mitochondrial pyruvate dehydrogenase (lipoamide) phosphatase complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of pyruvate dehydrogenase complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: pyruvate dehydrogenase phosphatase

Names: CG12151-PA; CG12151-PB; PDH phosphatase; Pdp-PA; Pdp-PB

NP_001245567.1

EC 3.1.3.16

EC 3.1.3.43

NP_572404.1

EC 3.1.3.16

EC 3.1.3.43

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

7731779..7734651 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001258638.2 → NP_001245567.1 pyruvate dehydrogenase phosphatase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245567.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9W3Q1

Conserved Domains (1) summary

cd00143
Location:58 → 394

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
NM_132176.4 → NP_572404.1 pyruvate dehydrogenase phosphatase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_572404.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9W3Q1

Related

FBpp0071033

Conserved Domains (1) summary

cd00143
Location:58 → 394

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...