sog short gastrulation [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: sogprovided by FlyBase
Official Full Name: short gastrulationprovided by FlyBase
Primary source: FLYBASE:FBgn0003463
Locus tag: Dmel_CG9224
See related: AllianceGenome:FB:FBgn0003463
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9224; Dm sog; Dmel\CG9224; l(1)G0160; l(1)G0395; l(1)G0479; Sog; SOG
Summary: Enables BMP binding activity; collagen binding activity; and protein sequestering activity. Involved in several processes, including amnioserosa formation; imaginal disc-derived wing vein morphogenesis; and regulation of BMP signaling pathway. Located in extracellular space. Is expressed in several structures, including amnioserosa anlage; epithelial cell; germ layer; imaginal disc; and neurogenic region. Orthologous to human CHRD (chordin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 13E1-13E3; 1-51 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (15603283..15633434, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (15497316..15527467, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

N-terminal and stem glycosylation controls extracellular Sog levels and distribution.
Title: N-linked glycosylation restricts the function of Short gastrulation to bind and shuttle BMPs.
These results suggest that synergistic interactions between Dl and Zld and between DI and Bcd are required for broad sog expression.
Title: The short gastrulation shadow enhancer employs dual modes of transcriptional synergy.
This does not occur through cell-autonomous crosstalk between cGMP and BMP signal transduction, but likely through altered extracellular activity of Sog.
Title: The Gyc76C Receptor Guanylyl Cyclase and the Foraging cGMP-Dependent Kinase Regulate Extracellular Matrix Organization and BMP Signaling in the Developing Wing of Drosophila melanogaster.
Data indicate that alphaPS1betaPS integrin receptors regulate the amount and type of Sog fragments available for diffusion in the extracellular space and impact Dpp function during oogenesis and pupal wing development.
Title: alphaPS1betaPS integrin receptors regulate the differential distribution of Sog fragments in polarized epithelia.
Cysteine repeat domains and adjacent sequences determine distinct morphogenetic protein modulatory activities of sog.
Title: Cysteine repeat domains and adjacent sequences determine distinct bone morphogenetic protein modulatory activities of the Drosophila Sog protein.
Sog and Cv promote BMP signaling by transporting a BMP heterodimer from the longitudinal veins into the crossvein regions.
Title: The crossveinless gene encodes a new member of the Twisted gastrulation family of BMP-binding proteins which, with Short gastrulation, promotes BMP signaling in the crossveins of the Drosophila wing.
sog acts during oogenesis to promote the formation of dorsal anterior structures of the eggshell and to establish the embryonic dorsal-ventral (DV) axis.
Title: Graded maternal short gastrulation protein contributes to embryonic dorsal-ventral patterning by delayed induction.
Robustness of the BMP morphogen gradient in Drosophila embryonic patterning
Title: Robustness of the BMP morphogen gradient in Drosophila embryonic patterning.
Results suggest that integrins act by binding and possibly regulating the activity/availability of different forms of Sog during pupal development through an adhesion independent mechanism.
Title: Integrins modulate Sog activity in the Drosophila wing.
The effects of site-directed mutagenesis of tolloid protein on its' ability to cleave Sog protein are reported.
Title: A complete domain structure of Drosophila tolloid is required for cleavage of short gastrulation.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables BMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables BMP binding	IDA Inferred from Direct Assay more info	PubMed
enables BMP binding	IPI Inferred from Physical Interaction more info	PubMed
enables collagen binding	IDA Inferred from Direct Assay more info	PubMed
enables protein sequestering activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in amnioserosa formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral pattern formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of protein localization to extracellular region	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maternal specification of dorsal/ventral axis, oocyte, soma encoded	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in posterior Malpighian tubule development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of imaginal disc-derived wing vein specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ring gland development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: short gastrulation

Names: CG9224-PA; CG9224-PB; CG9224-PE; chordin; short of gastrulation; short-gastrulation; sog-PA; sog-PB; sog-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

15603283..15633434 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001272649.2 → NP_001259578.1 short gastrulation, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259578.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B7FNI9, Q24025, Q9VXS7

UniProtKB/TrEMBL

M9PH73, Q3KN44

Conserved Domains (2) summary

smart00754
Location:594 → 708

CHRD; A domain in the BMP inhibitor chordin and in microbial proteins

pfam00093
Location:744 → 803

VWC; von Willebrand factor type C domain
NM_001272647.2 → NP_001259576.1 short gastrulation, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259576.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B7FNI9, Q24025, Q9VXS7

UniProtKB/TrEMBL

M9PH73, Q3KN44

Conserved Domains (2) summary

smart00754
Location:594 → 708

CHRD; A domain in the BMP inhibitor chordin and in microbial proteins

pfam00093
Location:744 → 803

VWC; von Willebrand factor type C domain
NM_057388.4 → NP_476736.1 short gastrulation, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476736.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B7FNI9, Q24025, Q9VXS7

UniProtKB/TrEMBL

M9PH73, Q3KN44

Related

FBpp0073879

Conserved Domains (2) summary

smart00754
Location:594 → 708

CHRD; A domain in the BMP inhibitor chordin and in microbial proteins

pfam00093
Location:744 → 803

VWC; von Willebrand factor type C domain