l(2)k09022 lethal (2) k09022 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: l(2)k09022provided by FlyBase
Official Full Name: lethal (2) k09022provided by FlyBase
Primary source: FLYBASE:FBgn0086451
Locus tag: Dmel_CG10805
See related: AllianceGenome:FB:FBgn0086451
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0118547.160; CG10805; Dmel\CG10805
Summary: Predicted to enable snoRNA binding activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and positive regulation of transcription by RNA polymerase I. Predicted to be part of 90S preribosome; small-subunit processome; and t-UTP complex. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in pancreatic ductal carcinoma. Orthologous to human HEATR1 (HEAT repeat containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (6854142..6860849)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (6854142..6860849)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables snoRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
involved_in neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase I	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of rRNA metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosomal small subunit biogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of 90S preribosome	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
part_of small-subunit processome	IBA Inferred from Biological aspect of Ancestor more info
part_of small-subunit processome	ISS Inferred from Sequence or Structural Similarity more info
part_of t-UTP complex	IBA Inferred from Biological aspect of Ancestor more info

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The following sections contain reference sequences that belong to a specific genome build. Explain