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    CG5793 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42505, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5793provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038858
    Locus tag
    Dmel_CG5793
    See related
    AllianceGenome:FB:FBgn0038858
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG5793; FBgn0038858
    Summary
    Predicted to enable acetylpyruvate hydrolase activity and oxaloacetate decarboxylase activity. Predicted to be involved in oxaloacetate metabolic process. Predicted to be active in mitochondrion. Is expressed in adult head and adult heart. Orthologous to human FAHD1 (fumarylacetoacetate hydrolase domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5793 in Genome Data Viewer
    Location:
    93C1-93C1; 3-71 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21127573..21129601)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16953295..16955323)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene peter pan Neighboring gene Bride of doubletime Neighboring gene supernumerary limbs Neighboring gene Odorant-binding protein 93a Neighboring gene Interacts with the C terminus of ELL 2 Neighboring gene tRNA methyltransferase 7-34

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Extensive tissue-specific expression variation and novel regulators underlying circadian behavior. Litovchenko M, et al. Sci Adv, 2021 Jan. PMID 33514540, Free PMC Article
    2. Tyrosine Metabolism Pathway Is Downregulated in Dopaminergic Neurons with LRRK2 Overexpression in Drosophila. Cheng J, et al. Int J Mol Sci, 2023 Oct 25. PMID 37958569, Free PMC Article
    3. Some novel intron positions in conserved Drosophila genes are caused by intron sliding or tandem duplication. Lehmann J, et al. BMC Evol Biol, 2010 May 26. PMID 20500887, Free PMC Article
    4. Mitochondrial-Y chromosome epistasis in Drosophila melanogaster. Ågren JA, et al. Proc Biol Sci, 2020 Oct 28. PMID 33081607, Free PMC Article
    5. The mitochondrial outer membrane protein MDI promotes local protein synthesis and mtDNA replication. Zhang Y, et al. EMBO J, 2016 May 17. PMID 27053724, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acetylpyruvate hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetylpyruvate hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxaloacetate decarboxylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in oxaloacetate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5793-PB
    CG5793-PD
    CG5793-PE
    NP_001247225.2
    NP_001247226.1
    NP_650944.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      21127573..21129601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260296.1 → NP_001247225.2  uncharacterized protein Dmel_CG5793, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247225.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T8S4, Q9VDE2
      Conserved Domains (2) summary
      COG0179
      Location:17 → 220
      MhpD; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport and catabolism]
      pfam01557
      Location:19 → 217
      FAA_hydrolase; Fumarylacetoacetate (FAA) hydrolase family

    2. NM_142687.3 → NP_650944.3  uncharacterized protein Dmel_CG5793, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650944.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T8S4, Q9VDE2
      Conserved Domains (2) summary
      COG0179
      Location:17 → 220
      MhpD; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport and catabolism]
      pfam01557
      Location:19 → 217
      FAA_hydrolase; Fumarylacetoacetate (FAA) hydrolase family

    3. NM_001260297.2 → NP_001247226.1  uncharacterized protein Dmel_CG5793, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247226.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T8S4, Q9VDE2
      Conserved Domains (2) summary
      COG0179
      Location:17 → 220
      MhpD; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport and catabolism]
      pfam01557
      Location:19 → 217
      FAA_hydrolase; Fumarylacetoacetate (FAA) hydrolase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T8S4 Q8T8S4
    Q9VDE2 Q9VDE2

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