jumu jumeau [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: jumuprovided by FlyBase
Official Full Name: jumeauprovided by FlyBase
Primary source: FLYBASE:FBgn0015396
Locus tag: Dmel_CG4029
See related: AllianceGenome:FB:FBgn0015396
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 5295; CG4029; Dmel\CG4029; Dmjumu; Dom; Dwhn; E(var)631; FoxN14; Jumeau; jumeaux; Jumu; jumu/Dom; l(3)06142; l(3)06439; Scim31; Whn
Summary: Enables transcription cis-regulatory region binding activity. Involved in several processes, including defense response to fungus; nucleolus organization; and positive regulation of receptor signaling pathway via JAK-STAT. Located in euchromatin; nucleolus; and polytene chromosome chromocenter. Is expressed in several structures, including RP neuron; ganglia; gonad; somatic precursor cell; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in T-cell immunodeficiency, congenital alopecia, and nail dystrophy; alopecia; nail disease; and primary immunodeficiency disease. Orthologous to human FOXN1 (forkhead box N1) and FOXN4 (forkhead box N4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 86B1-86B1; 3-49 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (10350182..10361612)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (6175904..6187334)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Jumu is required for the activation of JAK/STAT in Drosophila lymph gland development and epidermal wounds.
Title: Jumu is required for the activation of JAK/STAT in Drosophila lymph gland development and epidermal wounds.
The Drosophila Forkhead/Fox transcription factor Jumeau mediates specific cardiac progenitor cell divisions by regulating expression of the kinesin Nebbish.
Title: The Drosophila Forkhead/Fox transcription factor Jumeau mediates specific cardiac progenitor cell divisions by regulating expression of the kinesin Nebbish.
Loss of Jumeau (Jumu) function triggers apoptosis via a JNK-dependent pathway in wing development. jumu mutants show reduced wing size, a loss of the anterior cross vein (ACV) phenotype, and increased apoptosis. The JNK signaling markers puckered (puc) and p-JNK are increased in the wing discs of jumu mutants. Apoptosis induced by the loss of jumu is rescued by knocking down JNK.
Title: Drosophila jumu modulates apoptosis via a JNK-dependent pathway and is required for other processes in wing development.
Study reports that Drosophila protein Jumu binds N6-methyladenine (6mA)-marked DNA and acts as a maternal factor to regulate the maternal-to-zygotic transition and finds that zelda encoding the pioneer factor Zelda is marked by 6mA. Genetic assays suggest that Jumu controls the proper zygotic genome activation in early embryos, at least in part, by regulating zelda expression.
Title: 6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda.
Jumu is required for circulating hemocyte differentiation and phagocytosis in Drosophila
Title: Jumu is required for circulating hemocyte differentiation and phagocytosis in Drosophila.
The results suggest a Jumu-mediated crosstalk between hematopoiesis and the fat body, especially during the Toll-dependent formation of melanotic nodules.
Title: Overexpression of jumu induces melanotic nodules by activating Toll signaling in Drosophila.
Jumeau (Jumu), a member of the forkhead (Fkh) transcription factor family, controls hemocyte differentiation of lymph gland through multiple regulatory mechanisms.
Title: Dual role for Jumu in the control of hematopoietic progenitors in the Drosophila lymph gland.
Both jumu and CHES-1-like are required during asymmetric cell division for the derivation of two distinct cardiac cell types from their mutual precursor and in symmetric cell divisions that produce yet a third type of heart cell.
Title: Two forkhead transcription factors regulate the division of cardiac progenitor cells by a Polo-dependent pathway.
Mutations of the PEV-modifying jumu gene result in an extreme nucleolus disorganization.
Title: The winged-helix transcription factor JUMU regulates development, nucleolus morphology and function, and chromatin organization of Drosophila melanogaster.
The winged-helix transcription factor JUMU is a haplo-suppressor/triplo-enhancer of PEV in various tissues but exhibits reverse PEV effects in the brain of Drosophila melanogaster.
Title: The winged-helix transcription factor JUMU is a haplo-suppressor/triplo-enhancer of PEV in various tissues but exhibits reverse PEV effects in the brain of Drosophila melanogaster.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	TAS Traceable Author Statement more info	PubMed
involved_in embryonic heart tube development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleolus organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in euchromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome chromocenter	IDA Inferred from Direct Assay more info	PubMed