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    ProtA Protamine A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34866, updated on 17-Dec-2024

    Summary

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    Official Symbol
    ProtAprovided by FlyBase
    Official Full Name
    Protamine Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0013300
    Locus tag
    Dmel_CG4479
    See related
    AllianceGenome:FB:FBgn0013300
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:AT31403; BG:DS03431.2; CG4479; Dmel\CG4479; dProtA; mst35b; mst35B; mst35Ba; Mst35Ba; MST35Ba; protA
    Summary
    Involved in sperm DNA condensation. Located in chromatin and nucleus. Is expressed in late elongation-stage spermatid; primary spermatocyte; secondary spermatocyte; spermatozoon; and testis. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ProtA in Genome Data Viewer
    Location:
    35B6-35B7; 2-50 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (14879050..14881652, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (14879050..14881652, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45727 Neighboring gene Protamine B Neighboring gene long non-coding RNA:CR45302

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. No evidence for postcopulatory inbreeding avoidance in Drosophila melanogaster. Ala-Honkola O, et al. Evolution, 2011 Sep. PMID 21884066
    2. Covariance among premating, post-copulatory and viability fitness components in Drosophila melanogaster and their influence on paternity measurement. Droge-Young EM, et al. J Evol Biol, 2012 Aug. PMID 22587227
    3. Resolving mechanisms of competitive fertilization success in Drosophila melanogaster. Manier MK, et al. Science, 2010 Apr 16. PMID 20299550
    4. Mutation in Drosophila concentrative nucleoside transporter 1 alters spermatid maturation and mating behavior. Maaroufi HO, et al. Front Cell Dev Biol, 2022. PMID 36105362, Free PMC Article
    5. Wolbachia-mediated cytoplasmic incompatibility is associated with impaired histone deposition in the male pronucleus. Landmann F, et al. PLoS Pathog, 2009 Mar. PMID 19300496, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in sperm DNA condensation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sperm DNA condensation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sperm DNA condensation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sperm DNA condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatid development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protamine A
    Names
    CG4479-PA
    CG4479-PB
    Male-specific-transcript-35Ba
    ProtA-PA
    ProtA-PB
    ProtamineA
    dProtamineA
    protamine
    protamine (mst35Ba)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      14879050..14881652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057702.5 → NP_477050.1  protamine A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477050.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T3U9, Q9V3S3
      Related
      FBpp0080244
      Conserved Domains (1) summary
      pfam06382
      Location:60 → 146
      DUF1074; Protein of unknown function (DUF1074)

    2. NM_001299016.1 → NP_001285945.1  protamine A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285945.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T3U9, Q9V3S3
      Conserved Domains (1) summary
      pfam06382
      Location:60 → 146
      DUF1074; Protein of unknown function (DUF1074)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24401 Q24401
    Q24405 Q24405
    Q8T3U9 Q8T3U9
    Q9V3S3 Q9V3S3

    Gene LinkOut

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