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    unk unkempt [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42738, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unkprovided by FlyBase
    Official Full Name
    unkemptprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004395
    Locus tag
    Dmel_CG4620
    See related
    AllianceGenome:FB:FBgn0004395
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4620; Dmel\CG4620
    Summary
    Predicted to enable zinc ion binding activity. Involved in several processes, including chaeta morphogenesis; compound eye development; and imaginal disc-derived wing morphogenesis. Located in cytoplasm. Is expressed in several structures, including adult brain cell body rind; eye disc anterior to the morphogenetic furrow; eye disc posterior to the morphogenetic furrow; ommatidial precursor cluster; and presumptive embryonic/larval central nervous system. Orthologous to several human genes including UNK (unk zinc finger). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See unk in Genome Data Viewer
    Location:
    94E1-94E2; 3-78 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23149653..23157862, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18975375..18983584, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene hedgehog Neighboring gene Vacuolar H[+] ATPase AC39 subunit 2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The mTOR pathway component Unkempt regulates neural stem cell and neural progenitor cell cycle in the Drosophila central nervous system. Maierbrugger KT, et al. Dev Biol, 2020 May 1. PMID 31978396
    2. Segmentally restricted, cephalic expression of a leucine zipper gene during Drosophila embryogenesis. Mohler J, et al. Mech Dev, 1991 Mar. PMID 1911393
    3. The embryonically active gene, unkempt, of Drosophila encodes a Cys3His finger protein. Mohler J, et al. Genetics, 1992 Jun. PMID 1339381, Free PMC Article
    4. Modulation of alternative splicing by long-range RNA structures in Drosophila. Raker VA, et al. Nucleic Acids Res, 2009 Aug. PMID 19465384, Free PMC Article
    5. Headcase and Unkempt Regulate Tissue Growth and Cell Cycle Progression in Response to Nutrient Restriction. Li N, et al. Cell Rep, 2019 Jan 15. PMID 30650363, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The mTOR pathway component Unkempt regulates neural stem cell and neural progenitor cell cycle in the Drosophila central nervous system.
      Title: The mTOR pathway component Unkempt regulates neural stem cell and neural progenitor cell cycle in the Drosophila central nervous system.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables zinc ion binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chaeta morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in compound eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    unkempt
    Names
    CG4620-PA
    CG4620-PB
    CG4620-PC
    CG4620-PD
    CG4620-PE
    CG4620-PF
    CG4620-PG
    unk-PA
    unk-PB
    unk-PC
    unk-PD
    unk-PE
    unk-PF
    unk-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23149653..23157862 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275931.1 → NP_001262860.1  unkempt, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262860.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGS7
      Conserved Domains (3) summary
      COG3210
      Location:310 → 475
      FhaB; Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport]
      pfam00642
      Location:273 → 299
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam13920
      Location:553 → 598
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    2. NM_001260326.2 → NP_001247255.1  unkempt, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247255.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V397, Q24580, Q5BIG8, Q86B79, Q960U9
      UniProtKB/TrEMBL
      A0A0B4K6Y4
      Conserved Domains (3) summary
      COG3210
      Location:309 → 474
      FhaB; Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport]
      pfam00642
      Location:273 → 299
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam13920
      Location:552 → 597
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    3. NM_176545.3 → NP_788722.1  unkempt, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788722.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V397, Q24580, Q5BIG8, Q86B79, Q960U9
      UniProtKB/TrEMBL
      A0A0B4K6Y4
      Related
      FBpp0083794
      Conserved Domains (3) summary
      COG3210
      Location:309 → 474
      FhaB; Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport]
      pfam00642
      Location:273 → 299
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam13920
      Location:552 → 597
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    4. NM_001260324.2 → NP_001247253.1  unkempt, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247253.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V397, Q24580, Q5BIG8, Q86B79, Q960U9
      UniProtKB/TrEMBL
      A0A0B4K6Y4
      Conserved Domains (3) summary
      COG3210
      Location:309 → 474
      FhaB; Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport]
      pfam00642
      Location:273 → 299
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam13920
      Location:552 → 597
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    5. NM_001260325.2 → NP_001247254.1  unkempt, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247254.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7D1
      Conserved Domains (3) summary
      COG3210
      Location:311 → 547
      FhaB; Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport]
      pfam00642
      Location:273 → 299
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam13920
      Location:625 → 670
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    6. NM_001316501.1 → NP_001303430.1  unkempt, isoform G [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A126GV12
      Conserved Domains (3) summary
      COG3210
      Location:311 → 548
      FhaB; Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport]
      pfam00642
      Location:273 → 299
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam13920
      Location:626 → 671
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    7. NM_176546.3 → NP_788723.1  unkempt, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788723.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V397, Q24580, Q5BIG8, Q86B79, Q960U9
      UniProtKB/TrEMBL
      A0A0B4K6Y4
      Related
      FBpp0083795
      Conserved Domains (3) summary
      COG3210
      Location:309 → 474
      FhaB; Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport]
      pfam00642
      Location:273 → 299
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam13920
      Location:552 → 597
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6Y4 A0A0B4K6Y4
    A0A0B4K7D1 A0A0B4K7D1
    A0A0B4KGS7 A0A0B4KGS7
    A0A126GV12 A0A126GV12
    Q86B79.1 Q86B79

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