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    mRRF2 mitochondrial ribosome recycling factor 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42670, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mRRF2provided by FlyBase
    Official Full Name
    mitochondrial ribosome recycling factor 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0051159
    Locus tag
    Dmel_CG31159
    See related
    AllianceGenome:FB:FBgn0051159
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG31159; CG6943; dEF-G2; Dmel\CG31159; EF-G2
    Summary
    Predicted to enable GTPase activity. Predicted to be involved in mitochondrial translation and ribosome disassembly. Predicted to be located in mitochondrion. Is expressed in adult head. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 39. Orthologous to human GFM2 (GTP dependent ribosome recycling factor mitochondrial 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mRRF2 in Genome Data Viewer
    Location:
    94B6-94B6; 3-75 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22613686..22616622)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18439408..18442344)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Exchange factor for Arf 6 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L45 Neighboring gene locomotion defects Neighboring gene long non-coding RNA:CR43475

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila mitochondrial translation elongation factor G1 contains a nuclear localization signal and inhibits growth and DPP signaling. Trivigno C, et al. PLoS One, 2011 Feb 25. PMID 21364917, Free PMC Article
    2. The translation factors of Drosophila melanogaster. Marygold SJ, et al. Fly (Austin), 2017 Jan 2. PMID 27494710, Free PMC Article
    3. The genetic basis for variation in olfactory behavior in Drosophila melanogaster. Arya GH, et al. Chem Senses, 2015 May. PMID 25687947, Free PMC Article
    4. Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes. Phanse S, et al. Data Brief, 2016 Mar. PMID 26870755, Free PMC Article
    5. Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599810, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ribosome disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosome disassembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial ribosome recycling factor 2
    Names
    CG31159-PA
    CG31159-PB
    elongation factor G2
    mRRF2-PA
    mRRF2-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22613686..22616622
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170028.3 → NP_732771.2  mitochondrial ribosome recycling factor 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732771.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3KU70, F1JZV4, Q9VCX4
      UniProtKB/TrEMBL
      I1WYH6
      Conserved Domains (1) summary
      PRK12739
      Location:31 → 733
      PRK12739; elongation factor G; Reviewed

    2. NM_001300539.1 → NP_001287468.1  mitochondrial ribosome recycling factor 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287468.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LIH0
      Conserved Domains (5) summary
      TIGR00231
      Location:33 → 202
      small_GTP; small GTP-binding protein domain
      cd16262
      Location:447 → 522
      EFG_III; Domain III of Elongation Factor G (EFG)
      cl02787
      Location:323 → 403
      Translation_Factor_II_like; Domain II of Elongation factor Tu (EF-Tu)-like proteins
      cl02789
      Location:523 → 562
      EFG_like_IV; Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily ...
      cl21455
      Location:35 → 309
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LIH0 A0A0B4LIH0
    Q9VCX4.3 Q9VCX4

    Gene LinkOut

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