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    CG32444 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40406, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG32444provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0043783
    Locus tag
    Dmel_CG32444
    See related
    AllianceGenome:FB:FBgn0043783
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    aldose 1-epi; BcDNA:GH08902; CG12562; CG14576; CT3430; Dmel\CG32444
    Summary
    Predicted to enable aldose 1-epimerase activity. Predicted to be involved in galactose catabolic process via UDP-galactose and glucose metabolic process. Predicted to be located in cytosol. Is expressed in amnioserosa and spermatozoon. Human ortholog(s) of this gene implicated in galactosemia 4. Orthologous to human GALM (galactose mutarotase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG32444 in Genome Data Viewer
    Location:
    78E1-78E2; 3-47 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21636947..21639060)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21630047..21632160)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene ALG11, alpha-1,2-mannosyltransferase Neighboring gene Mediator complex subunit 1 Neighboring gene antisense RNA:CR45955 Neighboring gene Orosomucoid 1-like Neighboring gene uncharacterized protein Neighboring gene Antioxidant 1 copper chaperone

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. How Many Parameters Does It Take to Describe Disease Tolerance? Louie A, et al. PLoS Biol, 2016 Apr. PMID 27088212, Free PMC Article
    2. Copper homoeostasis in Drosophila melanogaster S2 cells. Southon A, et al. Biochem J, 2004 Oct 15. PMID 15239669, Free PMC Article
    3. Novel Drosophila model of myotonic dystrophy type 1: phenotypic characterization and genome-wide view of altered gene expression. Picchio L, et al. Hum Mol Genet, 2013 Jul 15. PMID 23525904
    4. The genomic basis of copper tolerance in Drosophila is shaped by a complex interplay of regulatory and environmental factors. Green L, et al. BMC Biol, 2022 Dec 8. PMID 36482348, Free PMC Article
    5. Compensatory cis-trans evolution and the dysregulation of gene expression in interspecific hybrids of Drosophila. Landry CR, et al. Genetics, 2005 Dec. PMID 16143608, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables aldose 1-epimerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldose 1-epimerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in galactose catabolic process via UDP-galactose IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in galactose catabolic process via UDP-galactose ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hexose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG32444-PA
    aldose 1-epimerase
    NP_730670.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21636947..21639060
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168930.2 → NP_730670.1  uncharacterized protein Dmel_CG32444 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730670.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXC3, Q9VP02, Q9VP03
      Related
      FBpp0078078
      Conserved Domains (1) summary
      cd09019
      Location:26 → 356
      galactose_mutarotase_like; galactose mutarotase_like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SXC3 Q8SXC3
    Q9VP02 Q9VP02

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