Def Defensin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Defprovided by FlyBase
Official Full Name: Defensinprovided by FlyBase
Primary source: FLYBASE:FBgn0010385
Locus tag: Dmel_CG1385
See related: AllianceGenome:FB:FBgn0010385
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 143607_at; CG1385; def; DEF; defensin; Dfn; DIM 26; Dmel\CG1385
Summary: Involved in antibacterial humoral response and defense response to Gram-positive bacterium. Located in extracellular space. Is expressed in adult fat body; embryonic/larval fat body; embryonic/larval hemolymph; and seminal receptacle. Used to study neurodegenerative disease. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (10054178..10054576, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (5941683..5942081, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	IEP Inferred from Expression Pattern more info	PubMed
involved_in antibacterial humoral response	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in defense response	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-positive bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to Gram-positive bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in defense response to bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in humoral immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in humoral immune response	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to bacterium	HEP more info	PubMed
involved_in response to bacterium	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed