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    CG3795 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31128, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG3795provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025378
    Locus tag
    Dmel_CG3795
    See related
    AllianceGenome:FB:FBgn0025378
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH24985; Dmel\CG3795; EG:9D2.4; SP160
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human KLK10 (kallikrein related peptidase 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG3795 in Genome Data Viewer
    Location:
    2B7-2B7; 1-0.2 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1708806..1710182, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1602839..1604215, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene b6 Neighboring gene a6 Neighboring gene Sarcoglycan delta Neighboring gene prage Neighboring gene Adenosine deaminase acting on RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. From sequence to chromosome: the tip of the X chromosome of D. melanogaster. Benos PV, et al. Science, 2000 Mar 24. PMID 10731137
    2. Molecular characterization of the singed wings locus of Drosophila melanogaster. Schwartz YB, et al. BMC Genet, 2004 Jun 9. PMID 15189568, Free PMC Article
    3. Damage sensing mediated by serine proteases Hayan and Persephone for Toll pathway activation in apoptosis-deficient flies. Nakano S, et al. PLoS Genet, 2023 Jun. PMID 37319131, Free PMC Article
    4. Serine proteases and their homologs in the Drosophila melanogaster genome: an initial analysis of sequence conservation and phylogenetic relationships. Ross J, et al. Gene, 2003 Jan 30. PMID 12568721
    5. Building a platform for predicting functions of serine protease-related proteins in Drosophila melanogaster and other insects. Cao X, et al. Insect Biochem Mol Biol, 2018 Dec. PMID 30367934, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG3795-PA
    CG3795-PB
    NP_001284790.1
    NP_569939.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1708806..1710182 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297861.1 → NP_001284790.1  uncharacterized protein Dmel_CG3795, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284790.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76920, Q8MRL2
      Conserved Domains (2) summary
      smart00020
      Location:60 → 278
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:60 → 281
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_130583.3 → NP_569939.2  uncharacterized protein Dmel_CG3795, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569939.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76920, Q8MRL2
      Related
      FBpp0070268
      Conserved Domains (2) summary
      smart00020
      Location:60 → 278
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:60 → 281
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76920 O76920
    Q8MRL2 Q8MRL2

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