Syx13 Syntaxin 13 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Syx13provided by FlyBase
Official Full Name: Syntaxin 13provided by FlyBase
Primary source: FLYBASE:FBgn0036341
Locus tag: Dmel_CG11278
See related: AllianceGenome:FB:FBgn0036341
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11278; Dm Syx13; Dmel\CG11278; DmSyx13; ff16; ff16 (69D1-70A2); l(3)01470; SYN13; Syx; syx13; Syx20
Summary: Predicted to enable SNAP receptor activity and SNARE binding activity. Involved in meiotic nuclear division; mitotic cell cycle; and secretory granule-lysosome fusion. Part of SNARE complex. Is expressed in adult head and organism. Orthologous to human TSNARE1 (t-SNARE domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (13044434..13046894)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (13037534..13039994)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Data show that syntaxin 13 (syx13) is a geneti modifier of the mutant CHMP2B (CHMP2BIntron5) eye phenotype.
Title: Syntaxin 13, a genetic modifier of mutant CHMP2B in frontotemporal dementia, is required for autophagosome maturation.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables SNAP receptor activity	IEA Inferred from Electronic Annotation more info
enables SNAP receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables SNARE binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in female meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in male meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in secretory granule-lysosome fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle docking	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in vesicle docking	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SNARE complex	IPI Inferred from Physical Interaction more info	PubMed
part_of SNARE complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Names: CG11278-PA; CG11278-PB; Syntaxin13; Syx13-PA; Syx13-PB; dSyntaxin13; syntaxin

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The following sections contain reference sequences that belong to a specific genome build. Explain