Nrk Neurospecific receptor kinase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Nrkprovided by FlyBase
Official Full Name: Neurospecific receptor kinaseprovided by FlyBase
Primary source: FLYBASE:FBgn0020391
Locus tag: Dmel_CG4007
See related: AllianceGenome:FB:FBgn0020391
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO2004063362.79; CG4007; Dmel\CG4007; DmHD-434; Dnrk; DNRK; HD-434; l(2)k14301; nrk; nrtk_dros; ROR2
Summary: Enables protein tyrosine kinase activity. Involved in muscle cell cellular homeostasis; neuron development; and signal transduction. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in neurogenic region; peripheral nervous system; and presumptive embryonic/larval central nervous system. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 9 and fetal akinesia deformation sequence syndrome 1. Orthologous to human MUSK (muscle associated receptor tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (13160063..13163484)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (9047568..9050989)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle cell cellular homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in muscle cell cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in rhabdomere development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

Names: CG4007-PA; Nrk-PA; drosophila neurospecific receptor kinase; neuronal receptor kinase; neurospecific receptor tyrosine kinase; neurotrophic receptor kinase; neurotropic receptor kinase

NP_477255.1

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