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    MTPAP mitochondrial poly(A) polymerase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31081, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MTPAPprovided by FlyBase
    Official Full Name
    mitochondrial poly(A) polymeraseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024360
    Locus tag
    Dmel_CG11418
    See related
    AllianceGenome:FB:FBgn0024360
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11418; Dmel\CG11418; dmmtpap; DmMTPAP; DmNP_569904; EG:8D8.8; SD27341p; TUTase1
    Summary
    Enables poly(A) RNA polymerase activity. Involved in mitochondrial mRNA 3'-end processing; mitochondrial mRNA polyadenylation; and tRNA stabilization. Located in mitochondrion. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; and posterior endoderm. Human ortholog(s) of this gene implicated in spastic ataxia 4. Orthologous to human MTPAP (mitochondrial poly(A) polymerase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MTPAP in Genome Data Viewer
    Location:
    1F4-1F4; 1-0.1 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1344872..1349357, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1238905..1243390, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene N(alpha)-acetyltransferase 30 A Neighboring gene Tetraspanin 2A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Defects of mitochondrial RNA turnover lead to the accumulation of double-stranded RNA in vivo. Pajak A, et al. PLoS Genet, 2019 Jul. PMID 31365523, Free PMC Article
    2. A regulatory cytoplasmic poly(A) polymerase in Caenorhabditis elegans. Wang L, et al. Nature, 2002 Sep 19. PMID 12239571
    3. Evolution of miRNA Tailing by 3' Terminal Uridylyl Transferases in Metazoa. Modepalli V, et al. Genome Biol Evol, 2017 Jun 1. PMID 28633361, Free PMC Article
    4. Mitochondrial Polyadenylation Is a One-Step Process Required for mRNA Integrity and tRNA Maturation. Bratic A, et al. PLoS Genet, 2016 May. PMID 27176048, Free PMC Article
    5. ER-mitochondrial contact protein Miga regulates autophagy through Atg14 and Uvrag. Xu L, et al. Cell Rep, 2022 Nov 1. PMID 36323251

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables poly(A) RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A) RNA polymerase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial mRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial mRNA polyadenylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial mRNA polyadenylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial poly(A) polymerase
    Names
    3' terminal uridylyl transferase 1
    CG11418-PA
    CG11418-PB
    CG11418-PC
    MTPAP-PA
    MTPAP-PB
    MTPAP-PC
    NP_001259129.1
    NP_569904.1
    NP_996325.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1344872..1349357 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272200.1 → NP_001259129.1  mitochondrial poly(A) polymerase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259129.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46102, O46103, Q8MRT1
      Conserved Domains (2) summary
      cd05402
      Location:193 → 333
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      pfam03828
      Location:427 → 477
      PAP_assoc; Cid1 family poly A polymerase

    2. NM_130548.3 → NP_569904.1  mitochondrial poly(A) polymerase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569904.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46102, O46103, Q8MRT1
      Related
      FBpp0070227
      Conserved Domains (2) summary
      cd05402
      Location:193 → 333
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      pfam03828
      Location:427 → 477
      PAP_assoc; Cid1 family poly A polymerase

    3. NM_206602.2 → NP_996325.1  mitochondrial poly(A) polymerase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996325.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KW16
      Conserved Domains (1) summary
      pfam03828
      Location:103 → 153
      PAP_assoc; Cid1 family poly A polymerase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O46102.2 O46102
    Q7KW16 Q7KW16

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