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    Prosalpha2 Proteasome alpha2 subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41531, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prosalpha2provided by FlyBase
    Official Full Name
    Proteasome alpha2 subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086134
    Locus tag
    Dmel_CG5266
    See related
    AllianceGenome:FB:FBgn0086134
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    153303_at; 20S-(a); 20S-alpha; alpha-2; Alpha-2; alpha2; alpha2_dm; CG5266; dalpha2; Dmel\CG5266; PRC3; Pros alpha2; PROS Dm25; PROS-Dm25g; pros25; Pros25; prosalpha2; Prot. 25 Kda; PSA2_DROME; Su(DTS); Su(DTS)-1
    Summary
    Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome core complex. Is expressed in adult head; adult heart; germline cell; and organism. Orthologous to human PSMA2 (proteasome 20S subunit alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Prosalpha2 in Genome Data Viewer
    Location:
    87B10-87B10; 3-52 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12431321..12432556)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8257043..8258278)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene N-acetylneuraminic acid synthase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Activator of SUMO 1 Neighboring gene Spliceosome-ribosome linker protein Neighboring gene Desaturase 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila proteasome Dm25 subunit substitutes the mouse MC3 subunit in hybrid proteasomes. The N-terminal domain is essential for subunit incorporation. Seelig A, et al. J Biol Chem, 1993 Dec 5. PMID 8244993
    2. Sequence and genomic organization of the Drosophila proteasome PROS-Dm25 gene. Seelig A, et al. Biochim Biophys Acta, 1993 Aug 19. PMID 8357840
    3. Inherently confinable split-drive systems in Drosophila. Terradas G, et al. Nat Commun, 2021 Mar 5. PMID 33674604, Free PMC Article
    4. Comparison survey of EVOO polyphenols and exploration of healthy aging-promoting properties of oleocanthal and oleacein. Nikou T, et al. Food Chem Toxicol, 2019 Mar. PMID 30677444
    5. The dominant temperature-sensitive lethal DTS7 of Drosophila melanogaster encodes an altered 20S proteasome beta-type subunit. Smyth KA, et al. Genetics, 1999 Jan. PMID 9872961, Free PMC Article

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Isolation and characterization of dominant suppressor of both Pros26' and Prosbeta2' that is a mutant allele of Pros25.
      Title: A genetic suppressor of two dominant temperature-sensitive lethal proteasome mutants of Drosophila melanogaster is itself a mutated proteasome subunit gene.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of proteasome complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome core complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    proteasome alpha2 subunit
    Names
    20s proteasome
    CG5266-PA
    Pros25
    Prosalpha2-PA
    Su(DTS)-1
    alpha-subunit of 20S proteasome
    alpha2
    alpha2 subunit
    proteasome 25kD subunit
    proteasome subunit alpha-type 2
    proteosome

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12431321..12432556
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079604.3 → NP_524328.1  proteasome alpha2 subunit [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524328.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P40301, Q9VG71
      Related
      FBpp0082062
      Conserved Domains (1) summary
      cd03750
      Location:6 → 231
      proteasome_alpha_type_2; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40301.1 P40301

    Gene LinkOut

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