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    grsm granny smith [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41587, updated on 9-Dec-2024

    Summary

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    Official Symbol
    grsmprovided by FlyBase
    Official Full Name
    granny smithprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040493
    Locus tag
    Dmel_CG7340
    See related
    AllianceGenome:FB:FBgn0040493
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD41548; CG7340; Dmel\CG7340; granny-smith; l(3)c00064
    Summary
    Enables metalloaminopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in cytoplasm. Is expressed in adult brain; adult head; adult heart; and adult pars intercerebralis. Orthologous to human NPEPL1 (aminopeptidase like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See grsm in Genome Data Viewer
    Location:
    87D5-87D5; 3-53 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12950042..12967712, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8775764..8793434, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene beaten path Vb Neighboring gene long non-coding RNA:CR44236 Neighboring gene Cytochrome P450 304a1 Neighboring gene Spc25 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expansion and functional diversification of a leucyl aminopeptidase family that encodes the major protein constituents of Drosophila sperm. Dorus S, et al. BMC Genomics, 2011 Apr 5. PMID 21466698, Free PMC Article
    2. A complementary transposon tool kit for Drosophila melanogaster using P and piggyBac. Thibault ST, et al. Nat Genet, 2004 Mar. PMID 14981521
    3. Sperm-Leucylaminopeptidases are required for male fertility as structural components of mitochondrial paracrystalline material in Drosophila melanogaster sperm. Laurinyecz B, et al. PLoS Genet, 2019 Feb. PMID 30802236, Free PMC Article
    4. Mitch a rapidly evolving component of the Ndc80 kinetochore complex required for correct chromosome segregation in Drosophila. Williams B, et al. J Cell Sci, 2007 Oct 15. PMID 17895365
    5. Genome-wide examination of the transcriptional response to ecdysteroids 20-hydroxyecdysone and ponasterone A in Drosophila melanogaster. Gonsalves SE, et al. BMC Genomics, 2011 Sep 29. PMID 21958154, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloaminopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    granny smith
    Names
    CG7340-PB
    CG7340-PF
    Leucyl-aminopeptidase
    aminopeptidase
    granny-smith
    grsm-PB
    grsm-PF
    lethal (3) c00064
    NP_650240.1
    NP_731749.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12950042..12967712 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169482.1 → NP_731749.3  granny smith, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731749.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0C4FEI8, Q8IH82
      Related
      FBtr0344095
      Conserved Domains (1) summary
      cd00433
      Location:141 → 628
      Peptidase_M17; Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and ...

    2. NM_141983.3 → NP_650240.1  granny smith, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650240.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NHV8, Q9V3D8, Q9VG18
      Related
      FBpp0082198
      Conserved Domains (1) summary
      cd00433
      Location:44 → 531
      Peptidase_M17; Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0C4FEI8 A0A0C4FEI8
    Q8IH82 Q8IH82
    Q9NHV8 Q9NHV8
    Q9V3D8 Q9V3D8

    Gene LinkOut

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