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    Nrg Neuroglian [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31792, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nrgprovided by FlyBase
    Official Full Name
    Neuroglianprovided by FlyBase
    Primary source
    FLYBASE:FBgn0264975
    Locus tag
    Dmel_CG1634
    See related
    AllianceGenome:FB:FBgn0264975
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ceb; CG1634; CT4318; Dmel\CG1634; fs(1)M72; ibx; l(1)7Fa; l(1)G0099; l(1)G0413; l(1)G0488; NFASC; Ngl; nrg; NRG; Nrg167; Nrg180; RA35
    Summary
    Enables calcium ion binding activity and cell adhesion molecule binding activity. Involved in several processes, including female mating behavior; melanotic encapsulation of foreign target; and nervous system development. Located in several cellular components, including filopodium; lateral plasma membrane; and pleated septate junction. Colocalizes with cytoneme. Is expressed in several structures, including brain; glial cell; hindgut; mushroom body; and synaptic neuropil subdomain. Used to study MASA syndrome and epilepsy. Human ortholog(s) of this gene implicated in MASA syndrome; hydrocephalus; ovarian carcinoma; pancreatic cancer; and schizophrenia. Orthologous to several human genes including CHL1 (cell adhesion molecule L1 like); NFASC (neurofascin); and NRCAM (neuronal cell adhesion molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nrg in Genome Data Viewer
    Location:
    7F2-7F4; 1-23 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8517373..8555170)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8411406..8449203)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43834 Neighboring gene ovarian tumor Neighboring gene uncharacterized protein Neighboring gene PIP82 Neighboring gene Integrator 4 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The analysis of genomic structures in the L1 family of cell adhesion molecules provides no evidence for exon shuffling events after the separation of arthropod and chordate lineages. Zhao G, et al. Gene, 1998 Jul 17. PMID 9666073
    2. Differential splicing generates a nervous system-specific form of Drosophila neuroglian. Hortsch M, et al. Neuron, 1990 May. PMID 1693086
    3. Application for the Drosophila ventral nerve cord standard in neuronal circuit reconstruction and in-depth analysis of mutant morphology. Boerner J, et al. J Neurogenet, 2010 Sep. PMID 20615087, Free PMC Article
    4. The L1-type cell adhesion molecule Neuroglian is necessary for maintenance of sensory axon advance in the Drosophila embryo. Martin V, et al. Neural Dev, 2008 Apr 8. PMID 18397531, Free PMC Article
    5. Postembryonic lineages of the Drosophila ventral nervous system: Neuroglian expression reveals the adult hemilineage associated fiber tracts in the adult thoracic neuromeres. Shepherd D, et al. J Comp Neurol, 2016 Sep 1. PMID 26878258, Free PMC Article

    See all (377) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neuroglian regulates Drosophila intestinal stem cell proliferation through enhanced signaling via the epidermal growth factor receptor.
      Title: Neuroglian regulates Drosophila intestinal stem cell proliferation through enhanced signaling via the epidermal growth factor receptor.
    2. Differential Neuroglian signaling in commissural pioneer interneurons not only prepatterns the olfactory contralateral tracts but also prevents the targeting of ingrowing sensory axons to their ipsilateral synaptic partners.
      Title: Pioneer interneurons instruct bilaterality in the Drosophila olfactory sensory map.
    3. In Drosophila, the L1CAM homolog Neuroglian (Nrg) is expressed as two isoforms. Epidermal Nrg167 encircles dendrites by interactions with dendritic Nrg180 to support dendrite growth, stabilization, and enclosure inside epidermis. Nrg180 forms homophilic interactions to facilitate axonal bundling.
      Title: Epidermis-Derived L1CAM Homolog Neuroglian Mediates Dendrite Enclosure and Blocks Heteroneuronal Dendrite Bundling.
    4. Dendrite pruning requires the developmentally regulated degradation of the cell adhesion molecule Neuroglian, and loss of Rab11 causes defects in the developmental degradation of Neuroglian and another target, the ion channel Ppk26.
      Title: Rab11 is required for neurite pruning and developmental membrane protein degradation in Drosophila sensory neurons.
    5. Prd1, alpha-Adaptin, and Unc-104 act in a common pathway to promote dendrite pruning by down-regulating Neuroglian protein.
      Title: Prd1 associates with the clathrin adaptor α-Adaptin and the kinesin-3 Imac/Unc-104 to govern dendrite pruning in Drosophila.
    6. An ankyrin-binding motif regulates nuclear levels of L1-type neuroglian and expression of the oncogene Myc in Drosophila neurons.
      Title: An ankyrin-binding motif regulates nuclear levels of L1-type neuroglian and expression of the oncogene Myc in Drosophila neurons.
    7. Neuroglian mediates adhesion between functionally distinct mushroom body axon populations to enforce and control appropriate projections into distinct axonal layers and lobes essential for olfactory learning and memory.
      Title: L1CAM/Neuroglian controls the axon-axon interactions establishing layered and lobular mushroom body architecture.
    8. Nrg plays a critical inhibitory role in dendrite pruning in dendritic arborization neurons.
      Title: Endocytic pathways downregulate the L1-type cell adhesion molecule neuroglian to promote dendrite pruning in Drosophila.
    9. Regulation of the interaction between Neuroglian and Ankyrin is an important novel module enabling local control of synaptic connectivity and function.
      Title: Transsynaptic coordination of synaptic growth, function, and stability by the L1-type CAM Neuroglian.
    10. Data describe the role of the L1-type CAM Neuroglian protein (NRG) in different steps of Drosophila mushroom body (MB) neuron axonogenesis.
      Title: The Drosophila L1CAM homolog Neuroglian signals through distinct pathways to control different aspects of mushroom body axon development.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cell adhesion molecule binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon ensheathment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell adhesion involved in heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in central complex development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of glial blood-brain barrier IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female courtship behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male courtship behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in melanotic encapsulation of foreign target IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in motor neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mushroom body development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nerve maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in photoreceptor cell axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of female receptivity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of tube size, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in septate junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with cytoneme IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in filopodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in pleated septate junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in septate junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neuroglian
    Names
    CG1634-PA
    CG1634-PB
    CG1634-PC
    CG1634-PD
    CG1634-PE
    CG1634-PF
    CG1634-PG
    CG1634-PH
    CG1634-PI
    Nrg-PA
    Nrg-PB
    Nrg-PC
    Nrg-PD
    Nrg-PE
    Nrg-PF
    Nrg-PG
    Nrg-PH
    Nrg-PI
    central brain deranged
    female sterile(1)M72
    icebox
    lethal (1) G0488

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      8517373..8555170
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169234.3 → NP_001162705.1  neuroglian, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162705.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V452, E1JJF8, E1JJF9, O61541, O61542, P20241, Q1WWD5, Q24414, Q24415, Q95U64, Q9V3X0
      UniProtKB/TrEMBL
      C0PTX6
      Conserved Domains (7) summary
      smart00410
      Location:57 → 127
      IG_like; Immunoglobulin like
      cd00063
      Location:917 → 1004
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:339 → 427
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:817 → 905
      fn3; Fibronectin type III domain
      pfam00047
      Location:525 → 609
      ig; Immunoglobulin domain
      pfam13882
      Location:1155 → 1235
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:55 → 128
      Ig; Immunoglobulin domain

    2. NM_001272408.1 → NP_001259337.1  neuroglian, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259337.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V452, E1JJF8, E1JJF9, O61541, O61542, P20241, Q1WWD5, Q24414, Q24415, Q95U64, Q9V3X0
      UniProtKB/TrEMBL
      C0PTX6
      Conserved Domains (7) summary
      smart00410
      Location:57 → 127
      IG_like; Immunoglobulin like
      cd00063
      Location:917 → 1004
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:339 → 427
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:817 → 905
      fn3; Fibronectin type III domain
      pfam00047
      Location:525 → 609
      ig; Immunoglobulin domain
      pfam13882
      Location:1155 → 1235
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:55 → 128
      Ig; Immunoglobulin domain

    3. NM_206657.4 → NP_996380.1  neuroglian, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996380.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PTX6
      Conserved Domains (7) summary
      smart00410
      Location:57 → 127
      IG_like; Immunoglobulin like
      cd00063
      Location:917 → 1004
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:339 → 427
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:817 → 905
      fn3; Fibronectin type III domain
      pfam00047
      Location:525 → 609
      ig; Immunoglobulin domain
      pfam13882
      Location:1155 → 1237
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:55 → 128
      Ig; Immunoglobulin domain

    4. NM_167160.2 → NP_727274.1  neuroglian, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727274.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V452, E1JJF8, E1JJF9, O61541, O61542, P20241, Q1WWD5, Q24414, Q24415, Q95U64, Q9V3X0
      UniProtKB/TrEMBL
      C0PTX6
      Related
      FBpp0071155
      Conserved Domains (7) summary
      smart00410
      Location:57 → 127
      IG_like; Immunoglobulin like
      cd00063
      Location:917 → 1004
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:339 → 427
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:817 → 905
      fn3; Fibronectin type III domain
      pfam00047
      Location:525 → 609
      ig; Immunoglobulin domain
      pfam13882
      Location:1155 → 1235
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:55 → 128
      Ig; Immunoglobulin domain

    5. NM_078535.3 → NP_511090.1  neuroglian, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511090.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PTX6
      Related
      FBpp0071154
      Conserved Domains (7) summary
      smart00410
      Location:57 → 127
      IG_like; Immunoglobulin like
      cd00063
      Location:917 → 1004
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:339 → 427
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:817 → 905
      fn3; Fibronectin type III domain
      pfam00047
      Location:525 → 609
      ig; Immunoglobulin domain
      pfam13882
      Location:1155 → 1237
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:55 → 128
      Ig; Immunoglobulin domain

    6. NM_001258652.1 → NP_001245581.1  neuroglian, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245581.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PTX6, M9NEZ5
      Conserved Domains (7) summary
      smart00410
      Location:57 → 127
      IG_like; Immunoglobulin like
      cd00063
      Location:917 → 1004
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:339 → 427
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:817 → 905
      fn3; Fibronectin type III domain
      pfam00047
      Location:525 → 609
      ig; Immunoglobulin domain
      pfam13882
      Location:1155 → 1221
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:55 → 128
      Ig; Immunoglobulin domain

    7. NM_001169235.1 → NP_001162706.1  neuroglian, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162706.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PTX6
      Conserved Domains (7) summary
      smart00410
      Location:57 → 127
      IG_like; Immunoglobulin like
      cd00063
      Location:917 → 1004
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:339 → 427
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:817 → 905
      fn3; Fibronectin type III domain
      pfam00047
      Location:525 → 609
      ig; Immunoglobulin domain
      pfam13882
      Location:1155 → 1237
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:55 → 128
      Ig; Immunoglobulin domain

    8. NM_001272407.2 → NP_001259336.1  neuroglian, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259336.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PTX6
      Conserved Domains (7) summary
      smart00410
      Location:57 → 127
      IG_like; Immunoglobulin like
      cd00063
      Location:917 → 1004
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:339 → 427
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:817 → 905
      fn3; Fibronectin type III domain
      pfam00047
      Location:525 → 609
      ig; Immunoglobulin domain
      pfam13882
      Location:1155 → 1237
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:55 → 128
      Ig; Immunoglobulin domain

    9. NM_001169233.2 → NP_001162704.1  neuroglian, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162704.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PTX6
      Conserved Domains (7) summary
      smart00410
      Location:57 → 127
      IG_like; Immunoglobulin like
      cd00063
      Location:917 → 1004
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:339 → 427
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:817 → 905
      fn3; Fibronectin type III domain
      pfam00047
      Location:525 → 609
      ig; Immunoglobulin domain
      pfam13882
      Location:1155 → 1237
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:55 → 128
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JJF8 E1JJF8
    E1JJF9 E1JJF9
    M9NEZ5 M9NEZ5
    P20241.2 P20241

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