Lam Lamin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Lamprovided by FlyBase
Official Full Name: Laminprovided by FlyBase
Primary source: FLYBASE:FBgn0002525
Locus tag: Dmel_CG6944
See related: AllianceGenome:FB:FBgn0002525
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 2459; 74/76; CG6944; D5; Dm; Dm(0); Dm0; Dm1; Dm2; Dmel\CG6944; DmLamin; Dmo; DmO; Dm[[0]]; Dm[[1]]; Dm[[2]]; Dm[[mit]]; Dm[[o]]; DM[[O]]; D[[m0]]; jf27; l(2)04643; l(2)25Ec; l(2)gdh-7; l(2)gdh7; l(2)jf27; lam; LAM; Lam Dm0; Lam Dm[[0]]; Lam(Dm0); lamB; LamB; LamDm; lamDm0; LamDm0; LamDmO; lamDm[[0]]; LamDm[[0]]; LamDm[[o]]; lamin; Lamin A; lamin B; Lamin B; lamin Dm0; Lamin Dm0; lamin DmO; lamin Dm[[0]]; Lamin Dm[[0]]; lamin-B; Lamin-B1; LaminA; LaminB; Lam[[Dm0]]; misg; nlam
Summary: Enables chromatin binding activity and signaling receptor binding activity. A structural constituent of cytoskeleton. Involved in several processes, including meiotic cytokinesis; nucleus organization; and positive regulation of cytoskeleton organization. Located in lamin filament and nuclear envelope lumen. Colocalizes with spindle envelope. Is expressed in several structures, including adult head; adult heart; somatic cell of testis; specialized Malpighian tubule cell; and spermatid cyst. Used to study myopathy. Human ortholog(s) of this gene implicated in several diseases, including brain disease (multiple); intrinsic cardiomyopathy (multiple); lipodystrophy (multiple); neuromuscular disease (multiple); and type 2 diabetes mellitus (multiple). Orthologous to human LMNA (lamin A/C); LMNB1 (lamin B1); and LMNB2 (lamin B2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 25E6-25E6; 2-17 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (5542480..5546642)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (5542480..5546642)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interaction with B-type lamin reveals the function of Drosophila Keap1 xenobiotic response factor in nuclear architecture.
Title: Interaction with B-type lamin reveals the function of Drosophila Keap1 xenobiotic response factor in nuclear architecture.
Reorganization of the nuclear architecture in the Drosophila melanogaster Lamin B mutant lacking the CaaX box.
Title: Reorganization of the nuclear architecture in the Drosophila melanogaster Lamin B mutant lacking the CaaX box.
Lamin is essential for nuclear localization of the GPI synthesis enzyme PIG-B and GPI-anchored protein production in Drosophila.
Title: Lamin is essential for nuclear localization of the GPI synthesis enzyme PIG-B and GPI-anchored protein production in Drosophila.
Indeed, aging phenotypes were suppressed by continued expression of Hey in enterocytes, suggesting that a Hey-lamin network safeguards nuclear organization and differentiated cell identity.
Title: The transcription factor Hey and nuclear lamins specify and maintain cell identity.
Study provides evidence that baculovirus infection induced lamin B phosphorylation and disruption of the nuclear lamina.
Title: Baculovirus infection induces disruption of the nuclear lamina.
findings reveal coordination of AGO2 and LaminB function to dictate genome architecture and thereby regulate gene expression
Title: Argonaute2 and LaminB modulate gene expression by controlling chromatin topology.
The loss of lamin-B leads to systemic inflammation and aging.
Title: Lamin-B in systemic inflammation, tissue homeostasis, and aging.
nuclear Wash interacts with B-type Lamin (Lamin Dm0), and, like Lamin, Wash associates with constitutive heterochromatin
Title: Wash interacts with lamin and affects global nuclear organization.
of single phosphorylation sites of Drosophila melanogaster lamin Dm and lamin C
Title: The different function of single phosphorylation sites of Drosophila melanogaster lamin Dm and lamin C.
Rab5 associated in vivo with nuclear Lamin and mushroom body defect (Mud), the Drosophila counterpart of nuclear mitotic apparatus protein (NuMA).
Title: Rab5 GTPase controls chromosome alignment through Lamin disassembly and relocation of the NuMA-like protein Mud to the poles during mitosis.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0092 (e-PCR)
- UniSTS:17157

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chitin-based cuticle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonad morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterochromatin formation	IDA Inferred from Direct Assay more info	PubMed
involved_in heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male meiosis cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiosis I cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic nuclear membrane reassembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear envelope organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear envelope organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear membrane organization	IDA Inferred from Direct Assay more info	PubMed
involved_in nuclear migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear pore localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear pore localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleus organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytokinesis, actomyosin contractile ring assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to nuclear envelope	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatocyte division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in terminal branching, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in lamin filament	IDA Inferred from Direct Assay more info	PubMed
located_in lamin filament	TAS Traceable Author Statement more info	PubMed
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope lumen	IDA Inferred from Direct Assay more info	PubMed
is_active_in nuclear lamina	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear lamina	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with spindle envelope	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: lamin

Names: B-type lamin; CG6944-PA; CG6944-PB; CG6944-PC; CG6944-PD; Lam-PA; Lam-PB; Lam-PC; Lam-PD; Lamin-B; LaminDm; LaminDm0; alpha-Lamin; intermediate filament-like lamina; lamin A; lamin B; lamin D; lamin D[[0]]; lamin D[[m0]]; lamin D[[m]]0; lamin D[[o]]; lamin Dm; lamin Dm0; lamin Dm[[0]]; lamin Dmo; lethal(2)25Ec; misguided; misrouted; n-lamin; nuclear lamin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

5542480..5546642

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001298700.1 → NP_001285629.1 lamin, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285629.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P08928, Q9VMQ0

UniProtKB/TrEMBL

A0A650BPI2, M9NE89

Conserved Domains (3) summary

pfam00038
Location:54 → 409

Filament; Intermediate filament protein

pfam00932
Location:466 → 572

LTD; Lamin Tail Domain

pfam10211
Location:283 → 377

Ax_dynein_light; Axonemal dynein light chain
NM_057268.5 → NP_476616.1 lamin, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476616.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P08928, Q9VMQ0

UniProtKB/TrEMBL

A0A650BPI2, M9NE89

Related

FBpp0078733

Conserved Domains (3) summary

pfam00038
Location:54 → 409

Filament; Intermediate filament protein

pfam00932
Location:466 → 572

LTD; Lamin Tail Domain

pfam10211
Location:283 → 377

Ax_dynein_light; Axonemal dynein light chain
NM_001258964.2 → NP_001245893.1 lamin, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245893.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P08928, Q9VMQ0

UniProtKB/TrEMBL

A0A650BPI2, M9NE89

Conserved Domains (3) summary

pfam00038
Location:54 → 409

Filament; Intermediate filament protein

pfam00932
Location:466 → 572

LTD; Lamin Tail Domain

pfam10211
Location:283 → 377

Ax_dynein_light; Axonemal dynein light chain
NM_001258963.2 → NP_001245892.1 lamin, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245892.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P08928, Q9VMQ0

UniProtKB/TrEMBL

A0A650BPI2, M9NE89

Conserved Domains (3) summary

pfam00038
Location:54 → 409

Filament; Intermediate filament protein

pfam00932
Location:466 → 572

LTD; Lamin Tail Domain

pfam10211
Location:283 → 377

Ax_dynein_light; Axonemal dynein light chain