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    LRR Leucine-rich repeat [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35715, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LRRprovided by FlyBase
    Official Full Name
    Leucine-rich repeatprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033212
    Locus tag
    Dmel_CG1399
    See related
    AllianceGenome:FB:FBgn0033212
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Carmil; CG1399; CG1576; Dmel\CG1399; Dmel\LRR
    Summary
    Involved in negative regulation of canonical NF-kappaB signal transduction and negative regulation of immune response. Located in muscle tendon junction. Is expressed in adult brain cell body rind and adult head. Human ortholog(s) of this gene implicated in immunodeficiency 58. Orthologous to several human genes including CARMIL1 (capping protein regulator and myosin 1 linker 1) and CARMIL3 (capping protein regulator and myosin 1 linker 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See LRR in Genome Data Viewer
    Location:
    43E9-43E11; 2-57 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7676540..7698902, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3564045..3586407, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene U2A Neighboring gene uncharacterized protein Neighboring gene Coenzyme Q9 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neonicotinoid clothianidin adversely affects insect immunity and promotes replication of a viral pathogen in honey bees. Di Prisco G, et al. Proc Natl Acad Sci U S A, 2013 Nov 12. PMID 24145453, Free PMC Article
    2. The Power of Drosophila melanogaster for Modeling Neonicotinoid Effects on Pollinators and Identifying Novel Mechanisms. Tasman K, et al. Front Physiol, 2021. PMID 33967830, Free PMC Article
    3. Disruption of the lipolysis pathway results in stem cell death through a sterile immunity-like pathway in adult Drosophila. Aggarwal P, et al. Cell Rep, 2022 Jun 21. PMID 35732115, Free PMC Article
    4. Combinatorial deployment of F-actin regulators to build complex 3D actin structures in vivo. Xie Y, et al. Elife, 2021 May 5. PMID 33949307, Free PMC Article
    5. The genetic basis of adaptation to copper pollution in Drosophila melanogaster. Everman ER, et al. Front Genet, 2023. PMID 37082199, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in negative regulation of canonical NF-kappaB signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in muscle tendon junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Leucine-rich repeat
    Names
    CG1399-PA
    CG1399-PB
    CG1399-PC
    CG1399-PD
    CG1399-PF
    CG1399-PG
    LRR-PA
    LRR-PB
    LRR-PC
    LRR-PD
    LRR-PF
    LRR-PG
    dcarmil
    leucine-rich repeat

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7676540..7698902 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273859.1 → NP_001260788.1  Leucine-rich repeat, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260788.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEE7
      Conserved Domains (4) summary
      cd00116
      Location:441 → 656
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:364 → 389
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:289 → 331
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:797 → 1108
      CARMIL_C; CARMIL C-terminus

    2. NM_001169605.1 → NP_001163076.1  Leucine-rich repeat, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163076.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NND6
      Conserved Domains (1) summary
      pfam16000
      Location:4 → 114
      CARMIL_C; CARMIL C-terminus

    3. NM_001169606.2 → NP_001163077.2  Leucine-rich repeat, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163077.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JGZ7
      Conserved Domains (3) summary
      cd00116
      Location:420 → 635
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:343 → 368
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16000
      Location:776 → 1080
      CARMIL_C; CARMIL C-terminus

    4. NM_001169604.2 → NP_001163075.1  Leucine-rich repeat, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163075.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JGZ8
      Conserved Domains (3) summary
      cd00116
      Location:420 → 635
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:343 → 368
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16000
      Location:776 → 1080
      CARMIL_C; CARMIL C-terminus

    5. NM_136472.6 → NP_610316.3  Leucine-rich repeat, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610316.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z734
      Conserved Domains (3) summary
      cd00116
      Location:443 → 658
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:366 → 391
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16000
      Location:799 → 1103
      CARMIL_C; CARMIL C-terminus

    6. NM_165549.4 → NP_724593.2  Leucine-rich repeat, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724593.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGL5
      Related
      FBpp0088014
      Conserved Domains (1) summary
      pfam16000
      Location:51 → 306
      CARMIL_C; CARMIL C-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEE7 A0A0B4KEE7
    A1Z734 A1Z734
    E1JGZ7 E1JGZ7
    E1JGZ8 E1JGZ8
    Q6NND6 Q6NND6
    Q8IGL5 Q8IGL5

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