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    CG11857 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43042, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG11857provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039303
    Locus tag
    Dmel_CG11857
    See related
    AllianceGenome:FB:FBgn0039303
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG11857
    Summary
    Involved in cell competition in a multicellular organism. Predicted to be located in membrane. Predicted to be active in Golgi membrane. Is expressed in several structures, including adult head; adult heart; anterior endoderm; embryonic/larval midgut primordium; and mesoderm. Orthologous to human RER1 (retention in endoplasmic reticulum sorting receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG11857 in Genome Data Viewer
    Location:
    96C8-96C8; 3-87 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25258898..25260759)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21084620..21086481)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Nucleoporin 37kD Neighboring gene Nucleoporin 358kD Neighboring gene antisense RNA:CR46099 Neighboring gene 3-ketodihydrosphingosine reductase Neighboring gene uncharacterized protein Neighboring gene Glutaminyl-tRNA synthetase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Maintenance of proteostasis by Drosophila Rer1 is essential for competitive cell survival and Myc-driven overgrowth. Paul PK, et al. PLoS Genet, 2024 Feb. PMID 38408084, Free PMC Article
    2. GMAP is an Atg8a-interacting protein that regulates Golgi turnover in Drosophila. Rahman A, et al. Cell Rep, 2022 May 31. PMID 35649355, Free PMC Article
    3. Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses. Vinci G, et al. PLoS One, 2008 Aug 6. PMID 18682733, Free PMC Article
    4. Evolutionary Dynamics of Abundant Stop Codon Readthrough. Jungreis I, et al. Mol Biol Evol, 2016 Dec. PMID 27604222, Free PMC Article
    5. Isolation of gene sets affected specifically by polyglutamine expression: implication of the TOR signaling pathway in neurodegeneration. Nelson B, et al. Cell Death Differ, 2005 Aug. PMID 15861189

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in cell competition in a multicellular organism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of cellular response to unfolded protein IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein retention in ER lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG11857-PA
    CG11857-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25258898..25260759
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143105.3 → NP_651362.1  uncharacterized protein Dmel_CG11857, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651362.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VBU6
      Related
      FBpp0084189
      Conserved Domains (1) summary
      pfam03248
      Location:17 → 185
      Rer1; Rer1 family

    2. NM_001316488.1 → NP_001303417.1  uncharacterized protein Dmel_CG11857, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A140SRF8
      Conserved Domains (1) summary
      pfam03248
      Location:17 → 185
      Rer1; Rer1 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A140SRF8 A0A140SRF8
    Q9VBU6 Q9VBU6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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