Su(H) Suppressor of Hairless [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Su(H)provided by FlyBase
Official Full Name: Suppressor of Hairlessprovided by FlyBase
Primary source: FLYBASE:FBgn0004837
Locus tag: Dmel_CG3497
See related: AllianceGenome:FB:FBgn0004837
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0257455.3; BG:DS00929.10; br7; C; CBF1; CG3497; CSL; D; dCSL; Dmel\CG3497; dRBP-Jk; dRBP-JK; dRBP-J[[Kappa]]; E(H); FTZ-F2; l(1)br7; l(2)35Bh; l(2)br7; l(2)k07904; oss; RBJK_DROME; RBP-J kappa; RBP-Jkappa; RBP-J[[Kappa]]; su(H); Su(h); SU(H); SuH; SUH; Su_H
Summary: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone acetyltransferase binding activity. Contributes to DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in several processes, including imaginal disc-derived appendage morphogenesis; regionalization; and regulation of transcription by RNA polymerase II. Located in cytoplasm; nucleus; and polytene chromosome. Part of CSL-Notch-Mastermind transcription factor complex and RNA polymerase II transcription repressor complex. Is expressed in several structures, including anlage in statu nascendi; brain; larval imaginal tissue; sensory nervous system primordium; and somatic precursor cell. Used to study Adams-Oliver syndrome and alcohol use disorder. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and dilated cardiomyopathy. Orthologous to human RBPJ (recombination signal binding protein for immunoglobulin kappa J region). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 35B8-35B8; 2-50 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (15039488..15043334)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (15039488..15043334)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Enhancers with cooperative Notch binding sites are more resistant to regulation by the Hairless co-repressor.
Title: Enhancers with cooperative Notch binding sites are more resistant to regulation by the Hairless co-repressor.
Membrane-Anchored Hairless Protein Restrains Notch Signaling Activity.
Title: Membrane-Anchored Hairless Protein Restrains Notch Signaling Activity.
RBPJ protein stability depends on protein complex formation with either H or NICD, similar to Su(H), demonstrating that the murine homologue underlies the same regulatory mechanisms as Su(H) in Drosophila. These results underscore the importance of regulating the availability of RBPJ protein to correctly mediate Notch signaling activity in the fly.
Title: An RBPJ-Drosophila Model Reveals Dependence of RBPJ Protein Stability on the Formation of Transcription-Regulator Complexes.
Study shows that Drosophila Notch/Su(H) signaling and the secreted fibrinogen-related protein Scabrous in mushroom body memory circuitry are important for the enduring preference of cues associated with alcohol's rewarding properties.
Title: Alcohol Activates Scabrous-Notch to Influence Associated Memories.
Phosphorylation of Suppressor of Hairless impedes its DNA-binding activity.
Title: Phosphorylation of Suppressor of Hairless impedes its DNA-binding activity.
complex genetic interactions of novel alleles deficient in co-repressor binding
Title: Complex genetic interactions of novel Suppressor of Hairless alleles deficient in co-repressor binding.
Structural models show that the Hairless-Su(H) repressor complexes from Daphnia and Drosophila are almost indistinguishable from one another. Amino acid residues in direct contact within the Hairless-Su(H) complex are at absolutely identical positions in the two homologues.
Title: Conservation of the Notch antagonist Hairless in arthropods: functional analysis of the crustacean Daphnia pulex Hairless gene.
biochemical analysis shows that A2BP1 is part of the Suppressor of Hairless [Su(H)] complex in the presence and absence of Notch
Title: Ataxin 2-binding protein 1 is a context-specific positive regulator of Notch signaling during neurogenesis in Drosophila melanogaster.
Su(H) protein levels depend on the interactions with H as well as with Notch.
Title: Hairless-binding deficient Suppressor of Hairless alleles reveal Su(H) protein levels are dependent on complex formation with Hairless.
X-ray structure of the Su(H)-Hairless complex bound to DNA.
Title: Structure and Function of the Su(H)-Hairless Repressor Complex, the Major Antagonist of Notch Signaling in Drosophila melanogaster.

Submit: New GeneRIF Correction See all GeneRIFs (32)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to DNA-binding transcription repressor activity, RNA polymerase II-specific	IGI Inferred from Genetic Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone acetyltransferase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in asymmetric cell division	TAS Traceable Author Statement more info	PubMed
involved_in cell fate determination	TAS Traceable Author Statement more info	PubMed
involved_in crystal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in dorsal/ventral lineage restriction, imaginal disc	NAS Non-traceable Author Statement more info	PubMed
involved_in hemopoiesis	TAS Traceable Author Statement more info	PubMed
involved_in imaginal disc-derived leg morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of compound eye cone cell fate specification	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in sensory organ precursor cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in wing disc dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of CSL-Notch-Mastermind transcription factor complex	IDA Inferred from Direct Assay more info	PubMed
part_of CSL-Notch-Mastermind transcription factor complex	IPI Inferred from Physical Interaction more info	PubMed
part_of RNA polymerase II transcription repressor complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IPI Inferred from Physical Interaction more info	PubMed
part_of transcription repressor complex	IGI Inferred from Genetic Interaction more info	PubMed

General protein information

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Preferred Names: suppressor of hairless

Names: CG3497-PA; CG3497-PC; Su(H)-PA; Su(H)-PC; lethal 7 in the black-reduced region; lethal group D; suppressor-of-hairless; supressor of hairless; transcription unit C

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

15039488..15043334

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057520.4 → NP_476868.1 suppressor of hairless, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476868.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P28159, Q3S1M8, Q9TVK8, Q9TVY7, Q9TW34, Q9U8F9, Q9V446

UniProtKB/TrEMBL

X2JAI1

Related

FBpp0080261

Conserved Domains (3) summary

cd01176
Location:424 → 520

IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...

pfam09270
Location:253 → 402

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:122 → 251

LAG1-DNAbind; LAG1, DNA binding
NM_001299019.1 → NP_001285948.1 suppressor of hairless, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285948.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P28159, Q3S1M8, Q9TVK8, Q9TVY7, Q9TW34, Q9U8F9, Q9V446

UniProtKB/TrEMBL

X2JAI1

Conserved Domains (3) summary

cd01176
Location:424 → 520

IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...

pfam09270
Location:253 → 402

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:122 → 251

LAG1-DNAbind; LAG1, DNA binding