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    CG30280 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37522, updated on 17-Dec-2024

    Summary

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    Official Symbol
    CG30280provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0050280
    Locus tag
    Dmel_CG30280
    See related
    AllianceGenome:FB:FBgn0050280
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AAF46801; CG6676; Dmel\CG30280; FBpp0071673
    Summary
    Predicted to be active in collagen-containing extracellular matrix and extracellular space. Orthologous to several human genes including FIBCD1 (fibrinogen C domain containing 1) and MFAP4 (microfibril associated protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG30280 in Genome Data Viewer
    Location:
    58B8-58B9; 2-98 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22113589..22114841)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18001094..18002346)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene flapper Neighboring gene Pleckstrin homology and RUN domain containing M1 Neighboring gene Verprolin 1 Neighboring gene uncharacterized protein Neighboring gene meiotic from via Salaria 332

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of the fibrinogen-like domain of fibrinogen-related proteins in the mosquito, Anopheles gambiae, and the fruitfly, Drosophila melanogaster, genomes. Wang X, et al. BMC Genomics, 2005 Sep 8. PMID 16150145, Free PMC Article
    2. Evolution and potential function of fibrinogen-like domains across twelve Drosophila species. Middha S, et al. BMC Genomics, 2008 May 30. PMID 18513432, Free PMC Article
    3. FlyXCDB-A Resource for Drosophila Cell Surface and Secreted Proteins and Their Extracellular Domains. Pei J, et al. J Mol Biol, 2018 Sep 14. PMID 29890119
    4. Comparative genome and proteome analysis of Anopheles gambiae and Drosophila melanogaster. Zdobnov EM, et al. Science, 2002 Oct 4. PMID 12364792
    5. Prolonged Exposure to Microgravity Reduces Cardiac Contractility and Initiates Remodeling in Drosophila. Walls S, et al. Cell Rep, 2020 Dec 8. PMID 33242407, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG30280-PD
    Fibrinogen-related protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22113589..22114841
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137797.5 → NP_611641.6  uncharacterized protein Dmel_CG30280 [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      E2RTZ8, Q4V4U2, Q9W291
      Conserved Domains (1) summary
      cd00087
      Location:65 → 279
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V4U2 Q4V4U2

    Gene LinkOut

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