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    psidin phagocyte signaling impaired [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42389, updated on 9-Dec-2024

    Summary

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    Official Symbol
    psidinprovided by FlyBase
    Official Full Name
    phagocyte signaling impairedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0243511
    Locus tag
    Dmel_CG4845
    See related
    AllianceGenome:FB:FBgn0243511
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4845; Dmel\CG4845; dNAA25; ird16; Naa25; psid; psif
    Summary
    Enables actin filament binding activity. Involved in several processes, including border follicle cell migration; positive regulation of lamellipodium assembly; and sensory neuron axon guidance. Located in growth cone lamellipodium and lysosome. Part of NatB complex. Is expressed in several structures, including brain; egg chamber; follicle cell; germline cell; and organism subdivision. Orthologous to human NAA25 (N-alpha-acetyltransferase 25, NatB auxiliary subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See psidin in Genome Data Viewer
    Location:
    92C1-92C1; 3-67 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20021704..20026482)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15847426..15852204)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class L Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene trade embargo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Maturation of NAA20 Aminoterminal End Is Essential to Assemble NatB N-Terminal Acetyltransferase Complex. Lasa M, et al. J Mol Biol, 2020 Nov 6. PMID 32976911
    2. Drosophila Psidin regulates olfactory neuron number and axon targeting through two distinct molecular mechanisms. Stephan D, et al. J Neurosci, 2012 Nov 14. PMID 23152593, Free PMC Article
    3. Psidin is required in Drosophila blood cells for both phagocytic degradation and immune activation of the fat body. Brennan CA, et al. Curr Biol, 2007 Jan 9. PMID 17208189
    4. Psidin, a conserved protein that regulates protrusion dynamics and cell migration. Kim JH, et al. Genes Dev, 2011 Apr 1. PMID 21406550, Free PMC Article
    5. Elimination of plasmatocytes by targeted apoptosis reveals their role in multiple aspects of the Drosophila immune response. Charroux B, et al. Proc Natl Acad Sci U S A, 2009 Jun 16. PMID 19482944, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NatB regulates Rb mutant cell death and tumor growth by modulating EGFR/MAPK signaling through the N-end rule pathways.
      Title: NatB regulates Rb mutant cell death and tumor growth by modulating EGFR/MAPK signaling through the N-end rule pathways.
    2. Psidin plays two independent developmental roles via the acquisition of separate signaling pathways, both of which contribute to the formation of olfactory circuits
      Title: Drosophila Psidin regulates olfactory neuron number and axon targeting through two distinct molecular mechanisms.
    3. Psid is an actin regulatory protein that plays a conserved role in protrusion dynamics and cell migration.
      Title: Psidin, a conserved protein that regulates protrusion dynamics and cell migration.
    4. encodes a lysosomal protein required in the blood cells for both degradation of engulfed bacteria and activation of fat-body Defensin
      Title: Psidin is required in Drosophila blood cells for both phagocytic degradation and immune activation of the fat body.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acetyltransferase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament depolymerization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in activation of immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of neuron apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phagocytosis, engulfment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of lamellipodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NatB complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NatB complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in growth cone lamellipodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phagocyte signaling impaired
    Names
    CG4845-PA
    N(alpha)-acetyltransferase 25
    immune response deficient 16
    psidin-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20021704..20026482
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142601.2 → NP_650858.1  phagocyte signaling impaired [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650858.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7YTX6, Q9VDQ7
      UniProtKB/TrEMBL
      U3Q053
      Related
      FBpp0083238
      Conserved Domains (3) summary
      sd00006
      Location:48 → 74
      TPR; TPR repeat [structural motif]
      pfam09797
      Location:264 → 642
      NatB_MDM20; N-acetyltransferase B complex (NatB) non catalytic subunit
      pfam13424
      Location:42 → 108
      TPR_12; Tetratricopeptide repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VDQ7.1 Q9VDQ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
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