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    Rpn5 Regulatory particle non-ATPase 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40717, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rpn5provided by FlyBase
    Official Full Name
    Regulatory particle non-ATPase 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0028690
    Locus tag
    Dmel_CG1100
    See related
    AllianceGenome:FB:FBgn0028690
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1100; Dmel\CG1100; p55; rpn5; RPN5
    Summary
    Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle. Is expressed in adult head; adult heart; and organism. Orthologous to human PSMD12 (proteasome 26S subunit, non-ATPase 12). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rpn5 in Genome Data Viewer
    Location:
    83C4-83C4; 3-47.5 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5789493..5791569)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1615215..1617291)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene jagunal Neighboring gene katanin p60-like 1 Neighboring gene Histone acetyltransferase 1 Neighboring gene Histone PARylation factor 1 Neighboring gene Proteasome assembly chaperone 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic evidence linking age-dependent attenuation of the 26S proteasome with the aging process. Tonoki A, et al. Mol Cell Biol, 2009 Feb. PMID 19075009, Free PMC Article
    2. The proteasomal subunit Rpn6 is a molecular clamp holding the core and regulatory subcomplexes together. Pathare GR, et al. Proc Natl Acad Sci U S A, 2012 Jan 3. PMID 22187461, Free PMC Article
    3. Assembly of the Drosophila 26 S proteasome is accompanied by extensive subunit rearrangements. Kurucz E, et al. Biochem J, 2002 Jul 15. PMID 11945175, Free PMC Article
    4. Zn2+-induced reversible dissociation of subunit Rpn10/p54 of the Drosophila 26 S proteasome. Kiss P, et al. Biochem J, 2005 Oct 15. PMID 15946124, Free PMC Article
    5. The regulatory complex of Drosophila melanogaster 26S proteasomes. Subunit composition and localization of a deubiquitylating enzyme. Hölzl H, et al. J Cell Biol, 2000 Jul 10. PMID 10893261, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome regulatory particle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome regulatory particle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of proteasome regulatory particle, lid subcomplex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome regulatory particle, lid subcomplex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    regulatory particle non-ATPase 5
    Names
    CG1100-PA
    Rpn5-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5789493..5791569
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141331.3 → NP_649588.1  regulatory particle non-ATPase 5 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649588.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3Z4
      Related
      FBpp0078278
      Conserved Domains (1) summary
      COG5071
      Location:13 → 496
      RPN5; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3Z4 Q9V3Z4

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