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    Adi1 Acireductone dioxygenase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 326189, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adi1provided by FlyBase
    Official Full Name
    Acireductone dioxygenase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0052068
    Locus tag
    Dmel_CG32068
    See related
    AllianceGenome:FB:FBgn0052068
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    adi1; CG32068; CG8000; Dadi1; Dmel\CG32068
    Summary
    Predicted to enable acireductone dioxygenase [iron(II)-requiring] activity. Involved in methionine biosynthetic process and positive regulation of reproductive process. Predicted to be located in cytoplasm; nucleus; and plasma membrane. Is expressed in adult head and organism. Orthologous to human ADI1 (acireductone dioxygenase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Adi1 in Genome Data Viewer
    Location:
    67E6-67E6; 3-33 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (10663376..10664435)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (10656476..10657535)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene simjang Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ADI1, a methionine salvage pathway enzyme, is required for Drosophila fecundity. Chou HY, et al. J Biomed Sci, 2014 Jul 19. PMID 25037729, Free PMC Article
    2. Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila. Parkhitko AA, et al. Genes Dev, 2016 Jun 15. PMID 27313316, Free PMC Article
    3. Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. Blanco E, et al. BMC Dev Biol, 2010 Sep 2. PMID 20813047, Free PMC Article
    4. Cold acclimation wholly reorganizes the Drosophila melanogaster transcriptome and metabolome. MacMillan HA, et al. Sci Rep, 2016 Jun 30. PMID 27357258, Free PMC Article
    5. Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes. Phanse S, et al. Data Brief, 2016 Mar. PMID 26870755, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acireductone dioxygenase [iron(II)-requiring] activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acireductone dioxygenase [iron(II)-requiring] activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-methionine salvage from methylthioadenosine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-methionine salvage from methylthioadenosine ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in methionine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in methionine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in methionine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    acireductone dioxygenase 1
    Names
    Adi1-PB
    CG32068-PB
    aci-reductone dioxygenase 1
    NP_001097577.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      10663376..10664435
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104107.2 → NP_001097577.1  acireductone dioxygenase 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097577.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6AWN0, Q8IQE4
      UniProtKB/TrEMBL
      F3YDM3
      Conserved Domains (1) summary
      cl21464
      Location:3 → 158
      cupin_like; Conserved domain found in cupin and related proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AWN0.2 Q6AWN0

    Gene LinkOut

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