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    dmGlut Dietary and metabolic glutamate transporter [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 47253, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dmGlutprovided by FlyBase
    Official Full Name
    Dietary and metabolic glutamate transporterprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010497
    Locus tag
    Dmel_CG5304
    See related
    AllianceGenome:FB:FBgn0010497
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.88; CG5304; Dmel\CG5304; DMGLUT; I(2)01810; l(2)01810; lethal(2)01810; MFS13
    Summary
    Enables high-affinity L-glutamate transmembrane transporter activity and sodium:phosphate symporter activity. Involved in L-glutamate import; positive regulation of mitochondrial fusion; and sodium-dependent phosphate transport. Located in plasma membrane. Is expressed in several structures, including brain; epithelial tube; gut section; head; and presumptive embryonic/larval system. Orthologous to human SLC17A2 (solute carrier family 17 member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dmGlut in Genome Data Viewer
    Location:
    33B9-33B9; 2-45 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12027438..12034122)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12027438..12034122)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene WD repeat domain 81 Neighboring gene long non-coding RNA:CR44587 Neighboring gene uncharacterized protein Neighboring gene Translocase of outer membrane 70 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. l(2)01810 is a novel type of glutamate transporter that is responsible for megamitochondrial formation. Shim MS, et al. Biochem J, 2011 Oct 15. PMID 21728998, Free PMC Article
    2. A comparative analysis of fruit fly and human glutamate dehydrogenases in Drosophila melanogaster sperm development. Vedelek V, et al. Front Cell Dev Biol, 2023. PMID 38020911, Free PMC Article
    3. Glutamate metabolism directs energetic trade-offs to shape host-pathogen susceptibility in Drosophila. Zhao X, et al. Cell Metab, 2021 Dec 7. PMID 34710355, Free PMC Article
    4. Embryonic expression patterns of Drosophila ACS family genes related to the human sialin gene. Laridon B, et al. Gene Expr Patterns, 2008 Apr. PMID 18255354
    5. Elevation of glutamine level by selenophosphate synthetase 1 knockdown induces megamitochondrial formation in Drosophila cells. Shim MS, et al. J Biol Chem, 2009 Nov 20. PMID 19755423, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables high-affinity L-glutamate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables sodium:phosphate symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sodium:phosphate symporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-glutamate import IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in sodium-dependent phosphate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sodium-dependent phosphate transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dietary and metabolic glutamate transporter
    Names
    CG5304-PA
    dmGlut-PA
    lethal (2) 01810

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      12027438..12034122
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138760.3 → NP_620115.2  dietary and metabolic glutamate transporter [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_620115.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      F2YPN7, Q9VKC9
      Related
      FBpp0079876
      Conserved Domains (2) summary
      cd06174
      Location:77 → 458
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00894
      Location:25 → 463
      2A0114euk; Na(+)-dependent inorganic phosphate cotransporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95R95 Q95R95
    Q9VKC9 Q9VKC9

    Gene LinkOut

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