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    pkaap pkaap [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34957, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pkaapprovided by FlyBase
    Official Full Name
    pkaapprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040079
    Locus tag
    Dmel_CG4132
    See related
    AllianceGenome:FB:FBgn0040079
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS02740.4; CG4132; Dmel\CG4132; DS02740.4
    Summary
    Predicted to enable protein kinase A binding activity. Predicted to be involved in protein localization. Predicted to be active in mitochondrion and plasma membrane. Orthologous to human AKAP10 (A-kinase anchoring protein 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pkaap in Genome Data Viewer
    Location:
    35F1-35F1; 2-52 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16288290..16291195)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16288290..16291195)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene cropped Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Pkaap regulates Rab4/Rab11-dependent traffic and Rab11 exocytosis of innate immune cargo. Sorvina A, et al. Biol Open, 2016 Jun 15. PMID 27190105, Free PMC Article
    2. The helix-loop-helix proteins dAP-4 and daughterless bind both in vitro and in vivo to SEBP3 sites required for transcriptional activation of the Drosophila gene Sgs-4. King-Jones K, et al. J Mol Biol, 1999 Aug 6. PMID 10438607
    3. A tissue specific cytochrome P450 required for the structure and function of Drosophila sensory organs. Willingham AT, et al. Mech Dev, 2004 Oct. PMID 15327788
    4. Genome annotation assessment in Drosophila melanogaster. Reese MG, et al. Genome Res, 2000 Apr. PMID 10779488, Free PMC Article
    5. Genie--gene finding in Drosophila melanogaster. Reese MG, et al. Genome Res, 2000 Apr. PMID 10779493, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein kinase A binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in antimicrobial peptide secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pkaap
    Names
    CG4132-PA
    pkaap-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16288290..16291195
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135939.3 → NP_609783.1  pkaap [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609783.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YU54, Q9V3I3
      Related
      FBpp0080384
      Conserved Domains (3) summary
      cd08721
      Location:324 → 444
      RGS_AKAP2_2; Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2
      cd12804
      Location:561 → 605
      AKAP10_AKB; PKA-binding (AKB) domain of A Kinase Anchor Protein 10
      cl02565
      Location:109 → 308
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7YU54 Q7YU54
    Q9V3I3 Q9V3I3

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