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    AANATL7 Arylalkylamine N-acetyltransferase-like 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31236, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AANATL7provided by FlyBase
    Official Full Name
    Arylalkylamine N-acetyltransferase-like 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0040376
    Locus tag
    Dmel_CG13759
    See related
    AllianceGenome:FB:FBgn0040376
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:AT19803; CG13759; CT33239; DmAANATL7; Dmel\CG13759; EG:BACR25B3.5
    Summary
    Predicted to enable aralkylamine N-acetyltransferase activity. Is expressed in adult head. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See AANATL7 in Genome Data Viewer
    Location:
    3A6-3A6; 1-1 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2580958..2583823)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2474991..2477856)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Pigment-dispersing factor receptor Neighboring gene Vacuolar H[+] ATPase 36kD subunit 3 Neighboring gene uncharacterized protein Neighboring gene will die slowly Neighboring gene egghead

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanistic and Structural Analysis of a Drosophila melanogaster Enzyme, Arylalkylamine N-Acetyltransferase Like 7, an Enzyme That Catalyzes the Formation of N-Acetylarylalkylamides and N-Acetylhistamine. Dempsey DR, et al. Biochemistry, 2015 Apr 28. PMID 25850002, Free PMC Article
    2. Probing the chemical mechanism and critical regulatory amino acid residues of Drosophila melanogaster arylalkylamine N-acyltransferase like 2. Dempsey DR, et al. Insect Biochem Mol Biol, 2015 Nov. PMID 26476413, Free PMC Article
    3. Insect Arylalkylamine N-Acyltransferases: Mechanism and Role in Fatty Acid Amide Biosynthesis. O'Flynn BG, et al. Front Mol Biosci, 2018. PMID 30094237, Free PMC Article
    4. The essential Drosophila melanogaster gene wds (will die slowly) codes for a WD-repeat protein with seven repeats. Hollmann M, et al. Mol Genet Genomics, 2002 Dec. PMID 12471440
    5. Purification, cloning, and characterization of a second arylalkylamine N-acetyltransferase from Drosophila melanogaster. Amherd R, et al. DNA Cell Biol, 2000 Nov. PMID 11098219

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Characterization of the kinetic mechanism of AANATL7 identified an ordered sequential mechanism, with acetyl-CoA binding first followed by histamine to generate an AANATL7.acetyl-CoA.histamine ternary complex prior to catalysis.
      Title: Mechanistic and Structural Analysis of a Drosophila melanogaster Enzyme, Arylalkylamine N-Acetyltransferase Like 7, an Enzyme That Catalyzes the Formation of N-Acetylarylalkylamides and N-Acetylhistamine.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aralkylamine N-acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    arylalkylamine N-acetyltransferase-like 7
    Names
    AANATL7-PA
    AANATL7-PB
    AANATL7-PC
    AANATL7-PD
    CG13759-PA
    CG13759-PB
    CG13759-PC
    CG13759-PD
    arylalkylamine N-Acetyltransferase like 7
    arylalkylamine N-Acetyltransferase-like 7
    NP_001188542.1
    NP_001188543.1
    NP_001188544.1
    NP_570009.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2580958..2583823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201613.2 → NP_001188542.1  arylalkylamine N-acetyltransferase-like 7, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188542.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T8X2, Q9NEF5, Q9W4Y1
      Conserved Domains (1) summary
      cl17182
      Location:128 → 187
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    2. NM_001201615.1 → NP_001188544.1  arylalkylamine N-acetyltransferase-like 7, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188544.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T8X2, Q9NEF5, Q9W4Y1
      Conserved Domains (1) summary
      cl17182
      Location:128 → 187
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    3. NM_130653.3 → NP_570009.2  arylalkylamine N-acetyltransferase-like 7, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_570009.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T8X2, Q9NEF5, Q9W4Y1
      Related
      FBpp0070421
      Conserved Domains (1) summary
      cl17182
      Location:128 → 187
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    4. NM_001201614.1 → NP_001188543.1  arylalkylamine N-acetyltransferase-like 7, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188543.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T8X2, Q9NEF5, Q9W4Y1
      Conserved Domains (1) summary
      cl17182
      Location:128 → 187
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T8X2 Q8T8X2
    Q9W4Y1 Q9W4Y1

    Gene LinkOut

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