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    magu magu [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36048, updated on 9-Dec-2024

    Summary

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    Official Symbol
    maguprovided by FlyBase
    Official Full Name
    maguprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262169
    Locus tag
    Dmel_CG2264
    See related
    AllianceGenome:FB:FBgn0262169
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2264; CT7504; Dmel\CG2264; pent; Pent; PENT
    Summary
    Enables heparan sulfate proteoglycan binding activity. Involved in determination of adult lifespan; germ-line stem cell population maintenance; and positive regulation of BMP signaling pathway. Located in extracellular region. Is expressed in hub cell; spermatozoon; and wing disc. Human ortholog(s) of this gene implicated in microphthalmia with limb anomalies. Orthologous to human SMOC1 (SPARC related modular calcium binding 1) and SMOC2 (SPARC related modular calcium binding 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See magu in Genome Data Viewer
    Location:
    46D9-46E1; 2-61 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10052541..10063712)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5940046..5951217)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene oysgedart Neighboring gene long non-coding RNA:CR44298 Neighboring gene antisense RNA:CR44297 Neighboring gene Cytochrome c oxidase subunit 7C Neighboring gene Cytochrome c oxidase subunit 7C-like Neighboring gene seele Neighboring gene Defensin Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class N Neighboring gene mitochondrial ribosomal protein L42 Neighboring gene Cdc2-related kinase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pentagone: patrolling BMP morphogen signaling. Vuilleumier R, et al. Fly (Austin), 2011 Jul-Sep. PMID 21406970
    2. Scaling of morphogen gradients. Ben-Zvi D, et al. Curr Opin Genet Dev, 2011 Dec. PMID 21873045
    3. Adult-specific over-expression of the Drosophila genes magu and hebe increases life span and modulates late-age female fecundity. Li Y, et al. Mol Genet Genomics, 2009 Feb. PMID 19011900, Free PMC Article
    4. SMOC can act as both an antagonist and an expander of BMP signaling. Thomas JT, et al. Elife, 2017 Mar 21. PMID 28323621, Free PMC Article
    5. Expansion-repression mechanism for scaling the Dpp activation gradient in Drosophila wing imaginal discs. Ben-Zvi D, et al. Curr Biol, 2011 Aug 23. PMID 21835621

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Scaling a Dpp Morphogen Gradient through Feedback Control of Receptors and Co-receptors.
      Title: Scaling a Dpp Morphogen Gradient through Feedback Control of Receptors and Co-receptors.
    2. The authors show that Pent internalises the Dpp co-receptors, the glypicans Dally and Dally-like protein (Dlp), and propose that this internalisation is important in the establishment of a long range Dpp gradient.
      Title: Pentagone internalises glypicans to fine-tune multiple signalling pathways.
    3. Pentagone, an important secreted feedback regulator of the pathway, plays a central role in scaling and acts as an expander of the Dpp gradient during disc growth
      Title: Dpp signaling activity requires Pentagone to scale with tissue size in the growing Drosophila wing imaginal disc.
    4. critical regulator of morphogen activity
      Title: Pentagone: patrolling BMP morphogen signaling.
    5. magu is required for germline stem cell self-renewal through BMP signaling in the Drosophila testis
      Title: magu is required for germline stem cell self-renewal through BMP signaling in the Drosophila testis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables extracellular matrix binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heparan sulfate proteoglycan binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heparin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in germ-line stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in basement membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    magu
    Names
    CG2264-PA
    CG2264-PB
    CG2264-PD
    CG2264-PF
    magu-PA
    magu-PB
    magu-PD
    magu-PF
    pentagone

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10052541..10063712
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165730.2 → NP_724871.1  magu, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724871.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E9E0, Q95TQ2
      Related
      FBpp0087489
      Conserved Domains (4) summary
      cd00104
      Location:38 → 77
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      cd00191
      Location:396 → 463
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:219 → 281
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam10591
      Location:180 → 274
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

    2. NM_001103784.2 → NP_001097254.1  magu, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097254.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4UZB1, Q86MK1
      Conserved Domains (4) summary
      cd00104
      Location:38 → 77
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      cd00191
      Location:303 → 370
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:219 → 281
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam10591
      Location:180 → 274
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

    3. NM_165732.2 → NP_724873.1  magu, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724873.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E9E0, Q95TQ2
      Related
      FBpp0087487
      Conserved Domains (4) summary
      cd00104
      Location:38 → 77
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      cd00191
      Location:396 → 463
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:219 → 281
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam10591
      Location:180 → 274
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

    4. NM_136704.3 → NP_610548.2  magu, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610548.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E9E0, Q95TQ2
      Related
      FBpp0087490
      Conserved Domains (4) summary
      cd00104
      Location:38 → 77
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      cd00191
      Location:396 → 463
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:219 → 281
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam10591
      Location:180 → 274
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4UZB1 A4UZB1
    Q0E9E0 Q0E9E0
    Q86MK1 Q86MK1
    Q95TQ2 Q95TQ2

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