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    Ucp4A Uncoupling protein 4A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32764, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ucp4Aprovided by FlyBase
    Official Full Name
    Uncoupling protein 4Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030872
    Locus tag
    Dmel_CG6492
    See related
    AllianceGenome:FB:FBgn0030872
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6492; Dmel\CG6492; dmUCP4a; DmUCP4A; ucp-4a; ucp4a; ucp4A; Ucp4a; UCP4A
    Summary
    Enables L-aspartate transmembrane transporter activity and uniporter activity. Involved in aspartate transmembrane transport; mitochondrial transmembrane transport; and response to oxidative stress. Is active in mitochondrial inner membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human SLC25A27 (solute carrier family 25 member 27). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ucp4A in Genome Data Viewer
    Location:
    16E1-16E1; 1-59 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17844949..17848223)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17738982..17742256)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44691 Neighboring gene uncharacterized protein Neighboring gene TBP-associated factor 9 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Spt7 Neighboring gene uncharacterized protein Neighboring gene Multicopper oxidase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila melanogaster Uncoupling Protein-4A (UCP4A) Catalyzes a Unidirectional Transport of Aspartate. Lunetti P, et al. Int J Mol Sci, 2022 Jan 18. PMID 35162943, Free PMC Article
    2. Light-driven activation of mitochondrial proton-motive force improves motor behaviors in a Drosophila model of Parkinson's disease. Imai Y, et al. Commun Biol, 2019. PMID 31799427, Free PMC Article
    3. UCP4C mediates uncoupled respiration in larvae of Drosophila melanogaster. Da-Ré C, et al. EMBO Rep, 2014 May. PMID 24639557, Free PMC Article
    4. Accessibility of the Drosophila genome discriminates PcG repression, H4K16 acetylation and replication timing. Bell O, et al. Nat Struct Mol Biol, 2010 Jul. PMID 20562853
    5. Mitochondrial uncoupling proteins and phylogenesis--UCP4 as the ancestral uncoupling protein. Hanák P, et al. FEBS Lett, 2001 Apr 27. PMID 11334880

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila melanogaster Uncoupling Protein-4A (UCP4A) Catalyzes a Unidirectional Transport of Aspartate.
      Title: Drosophila melanogaster Uncoupling Protein-4A (UCP4A) Catalyzes a Unidirectional Transport of Aspartate.
    2. results indicate that UCP4A prevents mitochondrial dysfunction and that modulation of UCP activity protects cells in a situation relevant for human Parkinson's disease
      Title: UCP4A protects against mitochondrial dysfunction and degeneration in pink1/parkin models of Parkinson's disease.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-aspartate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables uniporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aspartate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitochondrial transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to cold IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncoupling protein 4A
    Names
    CG6492-PA
    CG6492-PB
    CG6492-PC
    Ucp4A-PA
    Ucp4A-PB
    Ucp4A-PC
    uncoupling Protein-4A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      17844949..17848223
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201735.2 → NP_001188664.1  uncoupling protein 4A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188664.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VX14
      Conserved Domains (2) summary
      PTZ00169
      Location:39 → 335
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:248 → 336
      Mito_carr; Mitochondrial carrier protein

    2. NM_133018.4 → NP_573246.1  uncoupling protein 4A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573246.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VX14
      Related
      FBpp0074238
      Conserved Domains (2) summary
      PTZ00169
      Location:39 → 335
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:248 → 336
      Mito_carr; Mitochondrial carrier protein

    3. NM_001298463.1 → NP_001285392.1  uncoupling protein 4A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285392.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JL00
      Conserved Domains (1) summary
      pfam00153
      Location:39 → 81
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VX14 Q9VX14
    X2JL00 X2JL00

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