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    CG7376 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38715, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG7376provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035689
    Locus tag
    Dmel_CG7376
    See related
    AllianceGenome:FB:FBgn0035689
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG7376; SHPRH
    Summary
    Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in DNA damage response and protein polyubiquitination. Is expressed in spermatozoon. Orthologous to human SHPRH (SNF2 histone linker PHD RING helicase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG7376 in Genome Data Viewer
    Location:
    65A7-65A7; 3-16 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6174248..6178941)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6167348..6172041)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene PR/SET domain 13 Neighboring gene fiery mountain Neighboring gene uncharacterized protein Neighboring gene D19B Neighboring gene uncharacterized protein Neighboring gene D19A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The XNP remodeler targets dynamic chromatin in Drosophila. Schneiderman JI, et al. Proc Natl Acad Sci U S A, 2009 Aug 25. PMID 19706533, Free PMC Article
    2. The PHD finger, a nuclear protein-interaction domain. Bienz M. Trends Biochem Sci, 2006 Jan. PMID 16297627
    3. A screen for E3 ubiquitination ligases that genetically interact with the adaptor protein Cindr during Drosophila eye patterning. Ketosugbo KF, et al. PLoS One, 2017. PMID 29117266, Free PMC Article
    4. Genomic analysis of Drosophila neuronal remodeling: a role for the RNA-binding protein Boule as a negative regulator of axon pruning. Hoopfer ED, et al. J Neurosci, 2008 Jun 11. PMID 18550751, Free PMC Article
    5. Comprehensively surveying structure and function of RING domains from Drosophila melanogaster. Ying M, et al. PLoS One, 2011. PMID 21912646, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG7376-PA
    CG7376-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6174248..6178941
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274542.1 → NP_001261471.1  uncharacterized protein Dmel_CG7376, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261471.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IG89, Q9VRV2
      Conserved Domains (6) summary
      smart00028
      Location:636 → 669
      TPR; Tetratricopeptide repeats
      COG0553
      Location:1096 → 1238
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00162
      Location:1037 → 1083
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam00176
      Location:221 → 601
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:1108 → 1214
      Helicase_C; Helicase conserved C-terminal domain
      cl22851
      Location:281 → 320
      PHD_SF; PHD finger superfamily

    2. NM_139777.2 → NP_648034.1  uncharacterized protein Dmel_CG7376, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648034.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IG89, Q9VRV2
      Related
      FBpp0076706
      Conserved Domains (6) summary
      smart00028
      Location:636 → 669
      TPR; Tetratricopeptide repeats
      COG0553
      Location:1096 → 1238
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00162
      Location:1037 → 1083
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam00176
      Location:221 → 601
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:1108 → 1214
      Helicase_C; Helicase conserved C-terminal domain
      cl22851
      Location:281 → 320
      PHD_SF; PHD finger superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IG89 Q8IG89
    Q95TV0 Q95TV0
    Q9VRV2 Q9VRV2

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