U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    l(1)G0004 lethal (1) G0004 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33033, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    l(1)G0004provided by FlyBase
    Official Full Name
    lethal (1) G0004provided by FlyBase
    Primary source
    FLYBASE:FBgn0027334
    Locus tag
    Dmel_CG11738
    See related
    AllianceGenome:FB:FBgn0027334
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11738; Dmel\CG11738; l(G0004)
    Summary
    Predicted to enable RNA binding activity. Predicted to be located in nucleolus. Predicted to be active in nucleus. Is expressed in several structures, including anterior endoderm; dorsal pharyngeal muscle primordium; embryonic/larval midgut primordium; gut section; and larval muscle cell. Orthologous to human PNO1 (partner of NOB1 homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See l(1)G0004 in Genome Data Viewer
    Location:
    19C5-19C6; 1-64 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (20391447..20392401)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (20262474..20263428)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene jean-baptiste Neighboring gene Syntaxin 16 Neighboring gene HECT and RLD domain containing protein 2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Two rapidly evolving genes contribute to male fitness in Drosophila. Reinhardt JA, et al. J Mol Evol, 2013 Dec. PMID 24221639, Free PMC Article
    2. The non-dosage compensated Lsp1alpha gene of Drosophila melanogaster escapes acetylation by MOF in larval fat body nuclei, but is flanked by two dosage compensated genes. Weake VM, et al. BMC Mol Biol, 2007 May 19. PMID 17511883, Free PMC Article
    3. Genetic screening for modifiers of the DREF pathway in Drosophila melanogaster: identification and characterization of HP6 as a novel target of DREF. Ida H, et al. Nucleic Acids Res, 2009 Apr. PMID 19136464, Free PMC Article
    4. Genetic Basis of Increased Lifespan and Postponed Senescence in Drosophila melanogaster. Parker GA, et al. G3 (Bethesda), 2020 Mar 5. PMID 31969430, Free PMC Article
    5. A network model of the molecular organization of chromatin in Drosophila. van Bemmel JG, et al. Mol Cell, 2013 Feb 21. PMID 23438860

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    lethal (1) G0004
    Names
    CG11738-PA
    l(1)G0004-PA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      20391447..20392401
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134543.3 → NP_608387.1  lethal (1) G0004 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608387.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VR89
      Related
      FBpp0076990
      Conserved Domains (2) summary
      smart00322
      Location:165 → 217
      KH; K homology RNA-binding domain
      COG1094
      Location:61 → 239
      Krr1; rRNA processing protein Krr1/Pno1, contains KH domain [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VR89.1 Q9VR89

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools