Dhod Dihydroorotate dehydrogenase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Dhodprovided by FlyBase
Official Full Name: Dihydroorotate dehydrogenaseprovided by FlyBase
Primary source: FLYBASE:FBgn0000447
Locus tag: Dmel_CG9741
See related: AllianceGenome:FB:FBgn0000447
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9741; dhod; DHOD; DHODH; Dmel\CG9741; l(3)s3512
Summary: Enables dihydroorotate dehydrogenase (quinone) activity. Predicted to be involved in 'de novo' pyrimidine nucleobase biosynthetic process and pyrimidine ribonucleotide biosynthetic process. Located in mitochondrial intermembrane space. Is expressed in adult head; adult heart; male germline cell; primary spermatocyte cyst; and testis. Human ortholog(s) of this gene implicated in postaxial acrofacial dysostosis. Orthologous to human DHODH (dihydroorotate dehydrogenase (quinone)). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 85A5-85A5; 3-48 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (8651391..8652916, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (4477113..4478638, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables dihydroorotate dehydrogenase (quinone) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables dihydroorotate dehydrogenase (quinone) activity	ISS Inferred from Sequence or Structural Similarity more info
enables dihydroorotate dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dihydroorotate dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables dihydroorotate dehydrogenase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' pyrimidine nucleobase biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in 'de novo' pyrimidine nucleobase biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 'de novo' pyrimidine nucleobase biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in pyrimidine ribonucleotide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial intermembrane space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dihydroorotate dehydrogenase

Names: CG9741-PA; CG9741-PD; Dhod-PA; Dhod-PD

NP_477224.1

EC 1.3.-.-

NP_599138.3

EC 1.3.-.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

8651391..8652916 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_134311.3 → NP_599138.3 dihydroorotate dehydrogenase, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_599138.3

Status: REVIEWED

UniProtKB/Swiss-Prot

P32748, Q8INQ4, Q8INQ5, Q9VHP2

Conserved Domains (1) summary

cd04738
Location:51 → 379

DHOD_2_like; Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires ...
NM_057876.5 → NP_477224.1 dihydroorotate dehydrogenase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477224.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P32748, Q8INQ4, Q8INQ5, Q9VHP2

Related

FBpp0081376

Conserved Domains (1) summary

cd04738
Location:51 → 379

DHOD_2_like; Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires ...