Sirt4 Sirtuin 4 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Sirt4provided by FlyBase
Official Full Name: Sirtuin 4provided by FlyBase
Primary source: FLYBASE:FBgn0029783
Locus tag: Dmel_CG3187
See related: AllianceGenome:FB:FBgn0029783
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3187; D.mel3; Dmel\CG3187; dmSRT407; dSirt4; dSIRT4; SIRT4
Summary: Enables histone deacetylase activity. Involved in cellular response to starvation and determination of adult lifespan. Located in mitochondrion. Is expressed in several structures, including adult head; anlage in statu nascendi; antennal anlage; antennal primordium; and head epidermis primordium. Orthologous to human SIRT4 (sirtuin 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 5A10-5A10; 1-12 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (5664628..5665940, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (5558661..5559973, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sirt4 Modulates Oxidative Metabolism and Sensitivity to Rapamycin Through Species-Dependent Phenotypes in Drosophila mtDNA Haplotypes.
Title: Sirt4 Modulates Oxidative Metabolism and Sensitivity to Rapamycin Through Species-Dependent Phenotypes in Drosophila mtDNA Haplotypes.
Wolbachia and Sirtuin-4 interaction is associated with alterations in host glucose metabolism and bacterial titer.
Title: Wolbachia and Sirtuin-4 interaction is associated with alterations in host glucose metabolism and bacterial titer.
Further by assaying locomotion, a key correlate of aging, we demonstrate that dSirt4 null flies are severely physically impaired with a significant reduction in locomotion. In summary, we report that mitochondrial dSirt4 is a key determinant of longevity and its loss leads to early aging.
Title: Loss of mitochondrial SIRT4 shortens lifespan and leads to a decline in physical activity.
Sirt4 knockout flies have a short lifespan, with increased sensitivity to starvation and decreased fertility and activity.
Title: Sirt4 is a mitochondrial regulator of metabolism and lifespan in Drosophila melanogaster.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables NAD+ binding	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+ binding	IEA Inferred from Electronic Annotation more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables NAD-dependent protein lysine deacetylase activity	IEA Inferred from Electronic Annotation more info
enables NAD-dependent protein lysine deacetylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone deacetylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone deacetylase activity, NAD-dependent	IBA Inferred from Biological aspect of Ancestor more info
enables histone deacetylase activity, NAD-dependent	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: sirtuin 4

Names: CG3187-PA; CG3187-PB; CG3187-PC; Sirt4-PA; Sirt4-PB; Sirt4-PC

NP_572241.2

EC 2.4.2.30

EC 3.5.1.98

NP_727013.2

EC 2.4.2.30

EC 3.5.1.98

NP_727014.2

EC 2.4.2.30

EC 3.5.1.98

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

5664628..5665940 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_132013.3 → NP_572241.2 sirtuin 4, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_572241.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D0IQB9, Q8IRR5, Q9W4A1

Related

FBpp0070817

Conserved Domains (1) summary

cd01409
Location:38 → 299

SIRT4; SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...
NM_167041.3 → NP_727013.2 sirtuin 4, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727013.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8IRR5

Related

FBpp0070815

Conserved Domains (1) summary

cl00195
Location:1 → 216

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
NM_167042.3 → NP_727014.2 sirtuin 4, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727014.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8IRR5

Related

FBpp0070816

Conserved Domains (1) summary

cl00195
Location:1 → 216

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...